• Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders 

      Doan, Nhat Trung; Kaufmann, Tobias; Bettella, Francesco; Jørgensen, Kjetil Nordbø; Brandt, Christine Lycke; Moberget, Torgeir; Alnæs, Dag; Douaud, Gwenaëlle; Duff, Eugene; Djurovic, Srdjan; Melle, Ingrid; Ueland, Torill; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2017-06-09)
      The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ...
    • Enrichment of genetic markers of recent human evolution in educational and cognitive traits 

      Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-08-22)
      Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing ...
    • Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance 

      Akkouh, Ibrahim; Ueland, Torill; Andreassen, Ole Andreas; Brattbakk, Hans-Richard; Steen, Vidar Martin; Hughes, Timothy; Djurovic, Srdjan (Peer reviewed; Journal article, 2018-08-23)
      Memory is indispensable for normal cognitive functioning, and the ability to store and retrieve information is central to mental health and disease. The molecular mechanisms underlying complex memory functions are largely ...
    • Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence 

      Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019)
      Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ...
    • Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment 

      O`Connell, Kevin; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Fan, Chun C.; Askeland, Ragna Bugge; Knudsen, Gun Peggy Strømstad; Halmøy, Anne; Steen, Nils Eiel; Ueland, Torill; Walters, Bragi; Davíðsdóttir, Katrín; Haraldsdóttir, Gyda S.; Guðmundsson, Ólafur; Stefansson, Hreinn; Reichborn-Kjennerud, Ted; Haavik, Jan; Dale, Anders M.; Stefánsson, Kári; Djurovic, Srdjan; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified ...
    • Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients 

      Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill; Andreassen, Ole Andreas; Steen, Vidar Martin; Melle, Ingrid (Peer reviewed; Journal article, 2019-04-27)
      To investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two ...
    • A pilot study of cognitive remediation in remitted major depressive disorder patients 

      Hammar, Åsa; Semkovska, Maria; Borgen, Ida Maria Henriksen; Myklebost, Sunniva Brurok; Ronold, Eivind Haga; Sveen, Thea; Ueland, Torill; Porter, Richard; Johnson, Sheri L (Journal article; Peer reviewed, 2020)
      Major depressive disorder (MDD) is associated with working memory (WM) impairments. These deficits often persist following remission and are associated with rumination, a recognized risk factor for depression relapse. The ...
    • Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls 

      Engen, Magnus Johan; Lyngstad, Siv Hege; Ueland, Torill; Simonsen, Carmen Elisabeth; Vaskinn, Anja; Smeland, Olav Bjerkehagen; Bettella, Francesco; Lagerberg, Trine Vik; Djurovic, Srdjan; Andreassen, Ole Andreas; Melle, Ingrid (Journal article; Peer reviewed, 2020-11)
      Cognitive impairments are considered core features in schizophrenia and other psychotic disorders. Cognitive impairments are, to a lesser degree, also documented in healthy first-degree relatives. Although recent studies ...
    • A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue 

      Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R.; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2017-07)
      Objective: A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to the pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) and related comorbidities. We investigated the relative ...