Browsing Bergen Open Research Archive by Author "Ulvestad, Elling"
Now showing items 1-20 of 24
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Are white matter hyperintensities associated with neuroborreliosis? The answer is twofold
Lindland, Elisabeth Margrete Stokke; Røvang, Martin Soria; Solheim, Anne Marit; Andreassen, Silje; Skarstein, Ingerid; Dareez, Nazeer; MacIntosh, Bradley J.; Eikeland, Randi; Ljøstad, Unn; Mygland, Åse; Bos, Steffan D.; Ulvestad, Elling; Reiso, Harald; Lorentzen, Åslaug R.; Harbo, Hanne F.; Bjørnerud, Atle; Beyer, Mona K. (Journal article; Peer reviewed, 2024)Purpose Many consider white matter hyperintensities (WMHs) to be important imaging findings in neuroborreliosis. However, evidence regarding association with WMHs is of low quality. The objective was to investigate WMHs ... -
Bacteria and fungi in acute cholecystitis. A prospective study comparing next generation sequencing to culture
Dyrhovden, Ruben; Øvrebø, Kjell Kåre; Nordahl, Magnus Vie; Nygaard, Randi M.; Ulvestad, Elling; Kommedal, Øyvind (Peer reviewed; Journal article, 2020)Objectives: Guidelines for antibiotic treatment of acute cholecystitis are based on studies using culture techniques for microbial identification. Microbial culture has well described limitations and more comprehensive ... -
The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study
Dyrhovden, Ruben; Nygaard, RM; Patel, R; Ulvestad, Elling; Kommedal, Øyvind (Peer reviewed; Journal article, 2019)Objectives: The view of pleural empyema as a complication of bacterial pneumonia is changing because many patients lack evidence of underlying pneumonia. To further our understanding of pathophysiological mechanisms, we ... -
The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemic
Serigstad, Sondre; Markussen, Dagfinn Lunde; Ritz, Christian; Ebbesen, Marit Helen; Knoop, Siri Tandberg; Kommedal, Øyvind; Heggelund, Lars; Ulvestad, Elling; Bjørneklett, Rune Oskar; Grewal, Harleen (Journal article; Peer reviewed, 2022-09-30)Background: The COVID-19 pandemic was met with strict containment measures. We hypothesized that societal infection control measures would impact the number of hospital admissions for respiratory tract infections, as well ... -
Comparison of rapid molecular testing methods for detecting respiratory viruses in emergency care: a prospective study
Markussen, Dagfinn Lunde; Grewal, Harleen; Knoop, Siri Tandberg; Serigstad, Sondre; Kommedal, Øyvind; Ebbesen, Marit Helen; Ulvestad, Elling; Bjørneklett, Rune Oskar (Journal article; Peer reviewed, 2022)Background Respiratory tract infections (RTIs) caused by contagious viruses are common among patients presenting to the emergency department (ED). Early detection of these viruses can help prevent nosocomial transmissio ... -
The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing
Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Serigstad, Sondre; Knoop, Siri Tandberg; Ritz, Christian; Bjørneklett, Rune Oskar; Kommedal, Øyvind; Jenum, Synne; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2023)This prospective study assessed the value of initial microscopy evaluation of sputum samples submitted for rapid syndromic PCR-based testing. Bacterial detections by the BioFire FilmArray Pneumonia Panel plus in 126 high- ... -
Diagnostic utility of oropharyngeal swabs as an alternative to lower respiratory tract samples for PCR-based syndromic testing in patients with community-acquired pneumonia
Serigstad, Sondre; Knoop, Siri Tandberg; Markussen, Dagfinn Lunde; Ulvestad, Elling; Bjørneklett, Rune Oskar; Ebbesen, Marit Helen; Kommedal, Øyvind; Grewal, Harleen (Journal article; Peer reviewed, 2023)Syndromic PCR-based analysis of lower respiratory tract (LRT) samples in patients with community-acquired pneumonia (CAP) improves the bacterial yield and time-to-results compared to culture-based methods. However, obtaining ... -
Getting personal: Can systems medicine integrate scientific and humanistic conceptions of the patient?
Vogt, Henrik; Ulvestad, Elling; Eriksen, Thor Eirik; Getz, Linn (Peer reviewed; Journal article, 2014-12)Rationale, aims and objectives The practicing doctor, and most obviously the primary care clinician who encounters the full complexity of patients, faces several fundamental but intrinsically related theoretical and practical ... -
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
Siljan, William Ward; Sivakumaran, Dhanasekaran; Ritz, Christian; Jenum, Synne; Ottenhoff, Tom HM; Ulvestad, Elling; Holter, Jan Cato; Heggelund, Lars; Grewal, Harleen (Journal article; Peer reviewed, 2022)Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ... -
Humoral response to Epstein-Barr virus in patients with multiple sclerosis treated with B cell depletion therapy
Rød, Brit Ellen; Wergeland, Stig; Bjørnevik, Kjetil Lauvland; Holmøy, Trygve; Ulvestad, Elling; Njølstad, Gro; Myhr, Kjell-Morten; Torkildsen, Øivind (Journal article; Peer reviewed, 2023)Background B cell depletion therapy is highly effective in relapsing-remitting multiple sclerosis (RRMS). However, the precise underlying mechanisms of action for its biological effects in MS have still not been clarified. ... -
Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR)
Serigstad, Sondre; Ritz, Christian; Faurholt-Jepsen, Daniel; Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Kommedal, Øyvind; Bjørneklett, Rune Oskar; Heggelund, Lars; Clark, Tristan W.; van Werkhoven, Cornelis H.; Knoop, Siri Tandberg; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2022)Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ... -
In vitro-stimulated IL-6 monocyte secretion and in vivo peripheral blood T lymphocyte activation uniquely predicted 15-year survival in patients with head and neck squamous cell carcinoma
Aarstad, Helene Hersvik; Vintermyr, Olav Karsten; Ulvestad, Elling; Kross, Kenneth Wilfried; Heimdal, John-Helge; Aarstad, Hans Jørgen (Peer reviewed; Journal article, 2015-06-16)The study was performed in order to determine whether peripheral blood monocyte in vitro function, and lymphocyte in vivo activation at diagnosis, was associated with HPV tumor infection status and 15-year survival in head ... -
Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients
Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya (Peer reviewed; Journal article, 2017)Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. However, their presence in GBM tissue is still under debate, and evidence of their impact on functional ... -
Investigating the human jejunal microbiota
Villmones, Heidi Cecilie; Svanevik, Marius; Ulvestad, Elling; Stenstad, Tore; Anthonisen, Inger Lill; Nygaard, Randi Monsen; Dyrhovden, Ruben; Kommedal, Øyvind (Journal article; Peer reviewed, 2022)Descriptions of the small intestinal microbiota are deficient and conflicting. We aimed to get a reliable description of the jejunal bacterial microbiota by investigating samples from two separate jejunal segments collected ... -
Longitudinal investigation of a single variant SARS-CoV-2-outbreak in the immunologically naïve population of Ulvik, Norway
Mortensen, Nicolay; Wensaas, Knut-Arne; Solem, Unni; Sivertsen, Audun; Grewal, Harleen; Rørtveit, Guri; Ulvestad, Elling; Litleskare, Sverre (Journal article; Peer reviewed, 2024)Purpose To perform an extensive investigation of the clinical features and long-term complications among the n = 134 adults and children with nucleic acid amplification test (NAAT) verified SARS-CoV-2-infection in the ... -
Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers
Dyrhovden, Ruben; Rippin, Martin; Øvrebø, Kjell Kåre; Nygaard, Randi Monsen; Ulvestad, Elling; Kommedal, Øyvind (Journal article; Peer reviewed, 2021)In this article, we investigate patterns of microbial DNA contamination in targeted 16S rRNA amplicon sequencing (16S deep sequencing) and demonstrate how this can be used to filter background bacterial DNA in diagnostic ... -
Modulation of Transcriptional and Inflammatory Responses in Murine Macrophages by the Mycobacterium tuberculosis Mammalian Cell Entry (Mce) 1 Complex
Stavrum, Ruth; Stavrum, Anne-Kristin; Valvatne, Håvard; Riley, Lee W.; Ulvestad, Elling; Jonassen, Inge; Assmus, Jørg; Doherty, Tanya Mark; Grewal, Harleen M. S. (Peer reviewed; Journal article, 2011-10-24)The outcome of many infections depends on the initial interactions between agent and host. Aiming at elucidating the effect of the M. tuberculosis Mce1 protein complex on host transcriptional and immunological responses ... -
Protein and transcriptional biomarker profiling may inform treatment strategies in lower respiratory tract infections by indicating bacterial–viral differentiation
Sivakumaran, Dhanasekaran; Jenum, Synne; Markussen, Dagfinn Lunde; Serigstad, Sondre; Srivastava, Aashish; Saghaug, Christina Skår; Ulvestad, Elling; Knoop, Siri Tandberg; Grewal, Harleen (Journal article; Peer reviewed, 2024)Lower respiratory tract infections (LRTIs) remain a significant global cause of infectious disease-related mortality. Accurate discrimination between acute bacterial and viral LRTIs is crucial for optimal patient care, ... -
Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield
Serigstad, Sondre; Grewal, Harleen; Ebbesen, Marit Helen; Kommedal, Øyvind; Heggelund, Lars; van Werkhoven, Werkhoven; Faurholt-Jepsen, Daniel; Clark, T.W.; Ritz, Christian; Ulvestad, Elling; Bjørneklett, Rune Oskar; Knoop, Siri Tandberg; Ravn, P.; Markussen, Dagfinn Lunde (Journal article; Peer reviewed, 2022)Lack of rapid and comprehensive microbiological diagnosis in patients with community acquired pneumonia (CAP) hampers appropriate antimicrobial therapy. This study evaluates the real-world performance of the BioFire FilmArray ... -
Seroprevalence of antibodies to tick-borne encephalitis virus and Anaplasma phagocytophilum in healthy adults from western Norway
Hjetland, Reidar; Henningsson, Anna J.; Vainio, Kirsti; Dudman, Susanne Gjeruldsen; Grude, Nils; Ulvestad, Elling (Peer reviewed; Journal article, 2015)The aim of this study was to assess the seroprevalence of antibodies to tick-borne encephalitis virus (TBEV) and Anaplasma phagocytophilum in a healthy adult population from Sogn and Fjordane county in western Norway. Sera ...