Browsing Bergen Open Research Archive by Author "Ulvik, Arve"

Now showing items 1-20 of 38

    • The Association between Serum Serine and Glycine and Related-Metabolites with Pancreatic Cancer in a Prospective Cohort Study 

      Luu, Hung N.; Paragomi, Pedram; Wang, Renwei; Huang, Joyce Y.; Adams-Haduch, Jennifer; Midttun, Øivind; Ulvik, Arve; Nguyen, Tin C.; Brand, Randall E.; Gao, Yutang; Ueland, Per Magne; Yuan, Jian-Min (Journal article; Peer reviewed, 2022-04-28)
      Background: Serine and glycine play an important role in the folate-dependent one-carbon metabolism. The metabolism of serine and glycine has been shown to be associated with cancer cell proliferation. No prior epidemiologic ...

    • Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging 

      Dugué, Pierre-Antoine; Hodge, Allison M.; Ulvik, Arve; Ueland, Per Magne; Midttun, Øyvind; Rinaldi, Sabina; MacInnis, Robert J.; Li, Sherly X.; Meyer, Klaus; Navionis, Anne-Sophie; Flicker, Leon; Severi, Gianluca; English, Dallas R.; Vineis, Paolo; Tell, Grethe S.; Southey, Melissa C.; Milne, Roger L.; Giles, Graham G. (Journal article; Peer reviewed, 2022)
      Background Inflammation is a key feature of aging. We aimed to (i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality and (ii) develop a signature of ...

    • B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study 

      Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Bjørnestad, Espen Øglænd; Ulvik, Arve; Saeed, Sahrai; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)
      Background Calcium channel blockers (CCBs) are used for the treatment of cardiovascular disease (CVD), including angina pectoris, and hypertension; however, the effect on survival remains uncertain. CCBs impair fibrinolysis ...

    • Biomarkers of inflammation and left ventricular remodelling in psoriasis patients treated with infliximab 

      Midtbø, Helga Bergljot; Kringeland, Ester Anne; Gerdts, Eva; Ueland, Per Magne; Meyer, Klaus; Linde, Anja G; Ulvik, Arve; Jonsson, Roland; Tveit, Kåre Steinar (Journal article; Peer reviewed, 2022)
      Objective: Psoriasis is an immune mediated disorder associated with T cell activation and cardiovascular disease (CVD). We explored the association of inflammation with left ventricular (LV) remodelling in psoriasis patients ...

    • Changes in Tryptophan-Kynurenine Metabolism in Patients with Depression Undergoing ECT - A Systematic Review 

      Aarsland, Tore Ivar Malmei; Instanes, Johanne Telnes; Posserud, Maj-Britt Rocio; Ulvik, Arve; Kessler, Ute; Haavik, Jan (Journal article; Peer reviewed, 2022)
      The kynurenine pathway of tryptophan (Trp) metabolism generates multiple biologically active metabolites (kynurenines) that have been implicated in neuropsychiatric disorders. It has been suggested that modulation of ...

    • Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations 

      Midttun, Øivind; Theofylaktopoulou, Despoina; Mccann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I-Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian-Min; Butler, Lesley M.; Koh, Woon-Puay; Wang, Renwei; Gao, Yu-Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per Magne (Peer reviewed; Journal article, 2017-06)
      Background: Circulating concentrations of biomarkers that are related to vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the ...

    • Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation 

      Braadland, Peder Rustøen; Bergquist, Annika; Kummen, Martin; Bossen, Lars; Engesæter, Lise Katrine; Reims, Henrik Mikael; Bjørk, Ida Torunn; Grzyb, Krzysztof; Abildgaard, Andreas; Småstuen, Milada Cvancarova; Folseraas, Trine; Trøseid, Marius; Ulvik, Arve; Ueland, Per Magne; Melum, Espen; Line, Pål Dag; Høivik, Marte Lie; Grønbæk, Henning; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2023)
      Background and aims We previously demonstrated that people with primary sclerosing cholangitis (PSC) had reduced gut microbial capacity to produce active vitamin B6 (pyridoxal 5’-phosphate [PLP]), which corresponded to ...

    • A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Clasen, Joanna L; Heath, Alicia K.; Van Puyvelde, Heleen; Huybrechts, Inge; Park, Jin Young; Ferrari, Pietro; Johansson, Mattias; Scelo, Ghislaine; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Dahm, Christina C; Halkjær, Jytte; Olsen, Anja; Johnson, Theron; Katzke, Verena; Schulze, Matthias B; Masala, Giovanna; Segrado, Francesco; De Magistris, Maria Santucci; Sacerdote, Carlotta; Ocké, Marga C; Luján-Barroso, Leila; Ching-López, Ana; Huerta, José María; Ardanaz, Eva; Amiano, Pilar; Ericson, Ulrika; Manjer, Jonas; Gylling, Björn; Johansson, Ingegerd; Schmidt, Julie; Weiderpass, Elisabete; Riboli, Elio; Cross, Amanda J; Muller, David C (Journal article; Peer reviewed, 2021)
      Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. ...

    • Consumption of a light meal affects serum concentrations of one-carbon metabolites and B-vitamins. A clinical intervention study 

      Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim; Midttun, Øivind; Ulvik, Arve; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2022)
      The transfer of one-carbon units between molecules in metabolic pathways is essential for maintaining cellular homeostasis, but little is known about whether the circulating concentrations of metabolites involved in the ...

    • A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice 

      O'Keeffe, Maria; Oterhals, Åge; Weishaupt, Hrafn; Leh, Sabine; Ulvik, Arve; Ueland, Per Magne; Halstensen, Alfred; Marti, Hans Peter; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2023)
      Purpose The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish ...

    • The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression 

      Aarsland, Tore Ivar Malmei; Haavik, Jan; Ulvik, Arve; Ueland, Per Magne; Dols, Annemiek; Kessler, Ute (Journal article; Peer reviewed, 2023)
      Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while ...

    • The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites 

      Aarsland, Tore Ivar Malmei; Leskauskaite, Ieva; Midttun, Øivind; Ulvik, Arve; Ueland, Per Magne; Oltedal, Leif; Erchinger, Vera Jane; Ødegaard, Ketil Joachim; Haavik, Jan; Kessler, Ute (Peer reviewed; Journal article, 2019-05-31)
      Background: Prior studies suggest that activation of the tryptophan catabolism via the kynurenine pathway by proinflammatory cytokines may be involved in the pathophysiology of depression. Electroconvulsive therapy (ECT) ...

    • Exploratory analyses on the effect of time since last meal on concentrations of amino acids, lipids, one-carbon metabolites, and vitamins in the Hordaland Health Study 

      Anfinsen, Åslaug Matre; Rosendahl-Riise, Hanne; Nygård, Ottar Kjell; Tell, Grethe S.; Ueland, Per Magne; Ulvik, Arve; McCann, Adrian; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2023)
      Purpose Dietary intake may have pronounced effects on circulating biomarker concentrations. Therefore, the aim was to provide a descriptive overview of serum metabolite concentrations in relation to time since last meal, ...

    • Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: A randomised trial 

      Bratlie, Marianne; Hagen, Ingrid Valheim; Helland, Anita; Midttun, Øivind; Ulvik, Arve; Rosenlund, Grethe; Sveier, Harald; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2020)
      Low serum concentrations of several vitamins have been linked to increased risk of diseases including insulin resistance and type 2 diabetes (T2D). Fish is a good source of several vitamins, and the prevalence of T2D is ...

    • Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease 

      Knapskog, Anne Brita; Aksnes, Mari; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Saltvedt, Ingvild Tina; Giil, Lasse Melvær; Watne, Leiv (Journal article; Peer reviewed, 2023)
      Introduction: The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a possible ...

    • Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study 

      Monsen, Anne Lise Bjørke; Ulvik, Arve; Nilsen, Roy Miodini; Midttun, Øivind; Roth, Christine; Magnus, Per; Stoltenberg, Camilla; Vollset, Stein Emil; Reichborn-Kjennerud, Ted; Ueland, Per Magne (Peer reviewed; Journal article, 2016-11-30)
      Maternal nutrition and inflammation have been suggested as mediators in the development of various adverse pregnancy outcomes associated with maternal obesity. We have investigated the relation between pre-pregnancy BMI, ...

    • Inflammation, sex, blood pressure changes and hypertension in midlife: the Hordaland Health Study 

      Kringeland, Ester Anne; Gerdts, Eva; Ulvik, Arve; Tell, Grethe S.; Igland, Jannicke; Haugsgjerd, Teresa Risan; Ueland, Per Magne; Midtbø, Helga Bergljot (Journal article; Peer reviewed, 2023)
      Our aim was to test sex-specific associations of circulating markers of inflammation with blood pressure (BP) and incident hypertension in midlife. Participants in the Hordaland Health study (n = 3280, 56% women, mean age ...

    • Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery 

      Christensen, Monika; Fadnes, Dag Jone Stokke; Røst, Therese Halvorsen; Pedersen, Eva Ringdal; Andersen, John Roger; Våge, Villy; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Nygård, Ottar; Mellgren, Gunnar (Peer reviewed; Journal article, 2018-02-05)
      Objective: Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio ...

    • Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study 

      Apalset, Ellen M.; Gjesdal, Clara Gram; Ueland, Per Magne; Midttun, Øyvind; Ulvik, Arve; Eide, Geir Egil; Meyer, Klaus; Tell, Grethe Seppola (Peer reviewed; Journal article, 2014-04-24)
      The risk of osteoporosis increases in inflammatory disorders. In cell-mediated immune activation, interferon (IFN)-γ stimulates macrophage release of neopterin and increases the activity of indoleamine 2,3-dioxygenase ...

    • Interferon-γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study 

      Zuo, Hui; Tell, Grethe Seppola; Vollset, Stein Emil; Ueland, Per Magne; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve; Eussen, Simone (Peer reviewed; Journal article, 2014-06-19)
      Background It has been reported that interferon-γ (IFN-γ)–induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor ...