• Patient-derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways 

      Bischof, Katharina; Cremaschi, Andrea; Eroukhmanoff, Lena; Landskron, Johannes; Flage-Larsen, Lise-Lotte; Gade, Alexandra; Bjørge, Line; Urbanucci, Alfonso; Tasken, Kjetil (Journal article; Peer reviewed, 2025)
      Malignant ascites is commonly produced in advanced epithelial ovarian cancer (EOC) and serves as unique microenvironment for tumour cells. Acellular ascites fluid (AAF) is rich in signalling molecules and has been proposed ...
    • Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse 

      Taavitsainen, S.; Engedal, Nikolai; Cao, S.; Handle, Florian; Erickson, A.; Prekovic, Stefan; Wetterskog, D.; Tolonen, Teemu T.; Vuorinen, E.M.; Kiviaho, A.; Nätkin, R.; Häkkinen, T.; Devlies, W.; Henttinen, S.; Kaarijärvi, R.; Lahnalampi, M.; Kaljunen, H.; Nowakowska, K.; Syvälä, H.; Bläuer, M.; Cremaschi, P.; Claessens, Frank; Visakorpi, Tapio; Tammela, T.L.J.; Murtola, T.; Granberg, K.J.; Lamb, Alastair D.; Ketola, Kirsi; Mills, Ian; Attard, Gerhardt; Wang, W.; Nykter, Matti; Urbanucci, Alfonso (Journal article; Peer reviewed, 2021)
      Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and ...