• The association between visual display terminal use and dry eye: a review 

      Fjærvoll, Haakon Kristoffer Olsen; Fjærvoll, Ketil Andreas Olsen; Magnø, Morten Scherven; Moschowits, Emily; Vehof, Jelle; Dartt, Darlene A.; Utheim, Tor Paaske (Journal article; Peer reviewed, 2021)
      Background: Dry eye disease (DED) is a multifactorial disease of the tear film and ocular surface. It causes ocular symptoms, reduced quality of life and a considerable economic burden on society. Prolonged use of visual ...
    • Associations between Serial Intravitreal Injections and Dry Eye 

      Malmin, Agni; Thomseth, Vilde Marie; Førland, Per Tore; Khan, Ayyad Ahmad Zartasht; Hetland, Hanne Brit; Chen, Xiangjun; Haugen, Inga Britt Kjellevold; Utheim, Tor Paaske; Forsaa, Vegard Asgeir (Journal article; Peer reviewed, 2023)
      Purpose To investigate the effects of serial intravitreal injections (IVIs) on the ocular surface and meibomian glands (MGs) in patients treated with anti-vascular endothelial growth factor (anti-VEGF) for neovascular ...
    • Change in Ocular Surface Staining during Eyelid Warming Is Related to Tear Cytokine Levels 

      Landsend, Erlend Christoffer Sommer; Olafsson, Jonatan; Lai, Xiaoran; Aass, Hans Christian Dalsbotten; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      Purpose: To investigate the changes in the tear cytokine profile of patients with meibomian gland dysfunction (MGD) treated with eyelid warming and to correlate these changes with clinical parameters for dry eye disease ...
    • Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy 

      Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Rueegg, Corina Silvia; Baraas, Rigmor C.; Lagali, Neil; Bragadottir, Ragnheidur; Moe, Morten Carsten; Utheim, Tor Paaske (Peer reviewed; Journal article, 2019)
      Purpose: To investigate fundus autofluorescence (FAF) and other fundus manifestations in congenital aniridia. Methods: Fourteen patients with congenital aniridia and 14 age- and sex-matched healthy controls were examined. ...
    • A comparison between hyaluronic acid and other single ingredient eye drops for dry eye, a review 

      Hynnekleiv, Leif; Magnø, Morten Schjerven; Moschowits, Emily; Tønseth, Kim Alexander; Vehof, Jelle; Utheim, Tor Paaske (Journal article; Peer reviewed, 2023)
      Dry eye disease (DED) is a highly prevalent and debilitating condition. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a long history as a safe and effective DED treatment. HA is frequently used ...
    • Concise review: Altered versus unaltered amniotic membrane as a substrate for limbal epithelial cells 

      Utheim, Tor Paaske; Utheim, Øygunn Aass; Salvanos, Panagiotis; Jackson, Catherine; Schrader, Stefan; Geerling, Gerd; Sehic, Amer (Peer reviewed; Journal article, 2018-03-23)
      Limbal stem cell deficiency (LSCD) can result from a variety of corneal disorders, including chemical and thermal burns, infections, and autoimmune diseases. The symptoms of LSCD may include irritation, epiphora, blepharospasms, ...
    • Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells 

      Utheim, Øygunn Aass; Pasovic, Lara; Ræder, Sten; Eidet, Jon Roger; Fostad, Ida; Sehic, Amer; Roald, Borghild; de la Paz, Maria Fideliz; Lyberg, Torstein; Dartt, Darlene A.; Utheim, Tor Paaske (Peer reviewed; Journal article, 2019)
      Purpose Transplantation of limbal stem cells is a promising therapy for limbal stem cell deficiency. Limbal cells can be harvested from either a healthy part of the patient’s eye or the eye of a donor. Small explants are ...
    • High Throughput Screening of Additives Using Factorial Design to Promote Survival of Stored Cultured Epithelial Sheets 

      Reppe, Sjur; Jackson, Catherine; Ringstad, Håkon; Tønseth, Kim Alexander; Bakke, Hege Gilbø; Eidet, Jon Roger; Utheim, Tor Paaske (Peer reviewed; Journal article, 2018-11-18)
      There is a need to optimize storage conditions to preserve cell characteristics during transport of cultured cell sheets from specialized culture units to distant hospitals. In this study, we aimed to explore a method to ...
    • Hot towels: The bedrock of Meibomian gland dysfunction treatment – A review 

      Magnø, Morten Schjerven; Olafsson, Jonatan; Beining, Marie Wangen; Moschowits, Emily; Lagali, Neil Satish; Wolffsohn, James S.; Craig, Jennifer P.; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      Background Meibomian gland dysfunction (MGD) reduces quality-of-life and hinders work productivity of millions of patients, with high direct and indirect societal costs. Thickened meibum obstructs the glands and disrupts ...
    • Improvement of storage medium for cultured human retinal pigment epithelial cells using factorial design 

      Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Thiede, Bernd; Berg, Jens Petter; Messelt, Edvard Berger; Eidet, Jon Roger (Peer reviewed; Journal article, 2018-04-09)
      Storage of human retinal pigment epithelium (hRPE) can contribute to the advancement of cell-based RPE replacement therapies. The present study aimed to improve the quality of stored hRPE cultures by identifying storage ...
    • In-office thermal systems for the treatment of dry eye disease 

      Beining, Marie Wangen; Magnø, Morten Scherven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, ...
    • Intense pulsed light treatment in meibomian gland dysfunction: Past, present, and future 

      Fineide, Fredrik; Magnø, Morten Schjerven; Khan, Ayyad Ahmad Zartasht; Chen, Xiangjun; Vehof, Jelle; Utheim, Tor Paaske (Journal article; Peer reviewed, 2023)
      Dry eye disease is a highly prevalent condition, which can substantially impair quality of life, work productivity, and vision. It is considered an inflammatory disease and the most common cause is meibomian gland dysfunction. ...
    • The level of inflammatory tear cytokines is elevated in congenital Aniridia and associated with meibomian gland dysfunction 

      Landsend, Erlend Christoffer Sommer; Utheim, Øygunn Aass; Pedersen, Hilde Røgeberg; Aass, Hans Christian Dalsbotten; Lagali, Neil; Dartt, Darlene Ann; Baraas, Rigmor C.; Utheim, Tor Paaske (Peer reviewed; Journal article, 2018-04)
      Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid was ...
    • Predicting an unstable tear film through artificial intelligence 

      Fineide, Fredrik; Storås, Andrea; Chen, Xiangjun; Magnø, Morten Schjerven; Yazidi, Anis; Riegler, Michael; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      Dry eye disease is one of the most common ophthalmological complaints and is defined by a loss of tear film homeostasis. Establishing a diagnosis can be time-consuming, resource demanding and unpleasant for the patient. ...
    • Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers 

      Aqrawi, Lara Adnan; Galtung, Hilde; Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Utheim, Tor Paaske; Chen, Xiangjun; Utheim, Øygunn Aass; Palm, Øyvind; Skarstein, Kathrine; Jensen, Janicke Liaaen (Peer reviewed; Journal article, 2019-07-31)
      Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca ...
    • Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease 

      Fjærvoll, Ketil Andreas Olsen; Fjærvoll, Haakon Kristoffer Olsen; Magnø, Morten Scherven; Tellefsen Nøland, Sara Julie Maria; Dartt, Darlene Ann; Vehof, Jelle; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      Background: Visual display terminal (VDT) use is a key risk factor for dry eye disease (DED). Visual display terminal (VDT) use reduces the blink rate and increases the number of incomplete blinks. However, the exact ...
    • Role of stem cells in regenerative treatment of dry eye disease caused by lacrimal gland dysfunction 

      Jackson, Catherine Joan; Naqvi, Maria; Gundersen, Kjell Gunnar; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      An ageing population and increased screen use in younger people have contributed to a rise in incidence of dry eye disease (DED). Quality of life can be significantly affected by DED, with patients experiencing eye dryness, ...
    • Safety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturation 

      Stojanovic, Aleksandar; Chen, Xiangjun; Jin, Nan; Zhang, Ting; Stojanovic, Filip; Ræder, Sten; Utheim, Tor Paaske (Journal article; Peer reviewed, 2012)
      Purpose: To evaluate the efficacy and safety of epithelium-on corneal collagen cross-linking (CXL) using a multifactorial approach to achieve proper stromal riboflavin saturation. Methods: This non-randomized retrospective ...
    • Scanning electron microscopy observations of Loa loa (Nematoda) 

      Juul, Jens Anibal; Forsaa, Vegard Asgeir; Utheim, Tor Paaske; Willassen, Endre (Journal article; Peer reviewed, 2020)
      We present a case report of periocular Loa loa. The key feature of L. loa distinguishing it from other human filarial parasites are cuticular bosses, which are presented in images from a light microscope and a scanning ...
    • Seasonal variations in presenting symptoms and signs of dry eye disease in Norway 

      Eidet, Jon Roger; Chen, Xiangjun; Ræder, Sten; Badian, Reza; Utheim, Tor Paaske (Journal article; Peer reviewed, 2022)
      The study investigated the seasonal variations of presenting symptoms and signs of dry eye disease (DED) in Norway. 652 consecutive DED patients examined between August 2012 and May 2015 in Oslo, Norway, were included. ...