Browsing Bergen Open Research Archive by Author "Vaz, Mario"
Now showing items 1-11 of 11
-
Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management.
Dhanasakeran, S.; Jenum, Synne; Stavrum, Ruth; Wiker, Harald G.; Kenneth, John; Vaz, Mario; Doherty, Tanya Mark; Grewal, Harleen (Peer reviewed; Journal article, 2014-10-16)Background Non-tuberculous mycobacteria (NTM) are different from Mycobacterium tuberculosis (MTB) both in their ubiquitous environmental distribution and in their reduced capacity to cause disease. While often neglected ... -
The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy Indian adolescents
Jenum, Synne; Grewal, Harleen; Hokey, David A.; Kenneth, John; Vaz, Mario; Doherty, Timothy Mark; Jahnsen, Frode Lars (Peer reviewed; Journal article, 2014-07-03)Background: QuantiFERON-TB Gold In-Tube (QFT) is an IFNγ-release assay used in the diagnosis of Mycobacterium tuberculosis (MTB) infection. The risk of TB progression increases with the magnitude of the MTB-specific ... -
Host blood RNA transcript and protein signatures for sputum-independent diagnostics of tuberculosis in adults
Sivakumaran, Dhanasekaran; Ritz, Christian; Gjøen, John Espen; Vaz, Mario; Selvam, Sumithra; Ottenhoff, Tom H.M.; Doherty, Timothy Mark; Jenum, Synne; Grewal, Harleen (Journal article; Peer reviewed, 2021)To achieve the ambitious targets for tuberculosis (TB) prevention, care, and control stated by the End TB Strategy, new health care strategies, diagnostic tools are warranted. Host-derived biosignatures are explored for ... -
Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India
Sivakumaran, Dhanasekaran; Jenum, Synne; Srivastava, Aashish; Steen, Vidar Martin; Vaz, Mario; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Journal article; Peer reviewed, 2023-01-11)A large proportion of the global tuberculosis (TB) burden is asymptomatic and not detectable by symptom-based screening, driving the TB epidemic through continued M. tuberculosis transmission. Currently, no validated tools ... -
How participatory is parental consent in low literacy rural settings in low income countries? Lessons learned from a community based study of infants in South India
Rajaraman, Divya; Jesuraj, Nelson; Geiter, Lawrence; Bennett, Sean; Grewal, Harleen M. S.; Vaz, Mario; TB Trials Study Group (Peer reviewed; Journal article, 2011-02-15)Background A requisite for ethical human subjects research is that participation should be informed and voluntary. Participation during the informed consent process by way of asking questions is an indicator of the extent ... -
Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations
Bekken, Gry Klouman; Ritz, Christian; Selvam, Sumithra; Jesuraj, Nelson; Hesseling, Anneke; Doherty, T. Mark; Grewal, Harleen; Vaz, Mario; Jenum, Synne (Journal article; Peer reviewed, 2020-01-31)Background: The goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient and subclinical TB, recently defined by key stakeholders as “asymptomatic, early pre-clinical ... -
Improving Assignments for Therapeutic and Prophylactic Treatment Within TB Households. A Potential for Immuno-Diagnosis?
Sivakumaran, Dhanasekaran; Jenum, Synne; Ritz, Christian; Vaz, Mario; Doherty, Timothy Mark; Grewal, Harleen (Journal article; Peer reviewed, 2022-03-17)Delays in diagnosis and treatment of pulmonary tuberculosis (TB) can lead to more severe disease and increased transmission. Contact investigation among household contacts (HHCs) of TB patients is crucial to ensure optimal ... -
Incidence of tuberculosis among school-going adolescents in South India
Uppada, Dharma R.; Selvam, Sumithra; Jesuraj, Nelson; Lau, Esther L.; Doherty, T. M.; Grewal, Harleen; Vaz, Mario; Lindtjørn, Bernt (Peer reviewed; Journal article, 2016-07-26)Background: Tuberculosis (TB) incidence data in vaccine target populations, particularly adolescents, are important for designing and powering vaccine clinical trials. Little is known about the incidence of tuberculosis ... -
Influence of Age and Nutritional Status on the Performance of the Tuberculin Skin Test and QuantiFERON®-TB Gold In-Tube in Young Children Evaluated for Tuberculosis in Southern India.
Jenum, Synne; Selvam, Sumithra; Mahelai, Diana; Jesuraj, Nelson; Cardenas, Vicky; Kenneth, John; Hesseling, Anneke C.; Doherty, Tanya Mark; Vaz, Mario; Grewal, Harleen (Peer reviewed; Journal article, 2014-10)Background: Reliable identification of Mycobacterium tuberculosis infection or tuberculosis (TB) disease in young children is vital to assure adequate preventive and curative treatment. The tuberculin skin test (TST) and ... -
The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response
Uppada, Dharma Rao; Selvam, Sumithra; Jesuraj, Nelson; Bennett, Sean; Verver, Suzanne; Grewal, Harleen; Vaz, Mario (Peer reviewed; Journal article, 2014-11-18)Background. India has generally used 1 TU purified protein derivative (PPD) as opposed to 2 TU PPD globally, limiting comparisons. It is important to assess latent TB infection in adolescents given that they may be a target ... -
The tuberculin skin test in school going adolescents in South India: associations of socio-demographic and clinical characteristics with TST positivity and non-response
Uppada, Dharma Rao; Selvam, Sumithra; Jesuraj, Nelson; Bennett, Sean; Verver, Suzanne; Grewal, Harleen M. S.; Vaz, Mario; TB Trials Study Group (Peer reviewed; Journal article, 2014-11-18)Background: India has generally used 1 TU purified protein derivative (PPD) as opposed to 2 TU PPD globally, limiting comparisons. It is important to assess latent TB infection in adolescents given that they may be a target ...