Browsing Bergen Open Research Archive by Author "Veruki, Margaret Lin"
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AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy
Zandt, Bas-Jan; Liu, Jian Hao; Veruki, Margaret Lin; Hartveit, Espen (Peer reviewed; Journal article, 2016-02)AII amacrine cells have been found in all mammalian retinas examined and play an important role for visual processing under both scotopic and photopic conditions. Whereas ultrastructural investigations have provided a ... -
AMPA receptors at ribbon synapses in the mammalian retina: kinetic models and molecular identity
Hartveit, Espen; Zandt, Bas-Jan; Madsen, Eirik; Castilho, Aurea; Mørkve, Svein Harald; Veruki, Margaret Lin (Peer reviewed; Journal article, 2018)In chemical synapses, neurotransmitter molecules released from presynaptic vesicles activate populations of postsynaptic receptors that vary in functional properties depending on their subunit composition. Differential ... -
Capacitance measurement of dendritic exocytosis in an electrically coupled inhibitory retinal interneuron: an experimental and computational study
Hartveit, Espen; Veruki, Margaret Lin; Zandt, Bas-Jan (Peer reviewed; Journal article, 2019-08-04)Exocytotic release of neurotransmitter can be quantified by electrophysiological recording from postsynaptic neurons. Alternatively, fusion of synaptic vesicles with the cell membrane can be measured as increased capacitance ... -
Combining microiontophoresis and multiphoton excitation microscopy to investigate neuronal signaling
Hartveit, Espen; Veruki, Margaret Lin (Neuromethods, Chapter; Peer reviewed, 2019)Multiphoton excitation (MPE) microscopy allows subcellular structural and functional imaging of neurons and can be combined with techniques for activating postsynaptic receptors at spatial and temporal scales that mimic ... -
Dendritic morphology of an inhibitory retinal interneuron enables simultaneous local and global synaptic integration
Hartveit, Espen; Veruki, Margaret Lin; Zandt, Bas-Jan (Journal article; Peer reviewed, 2022) -
Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells
Castilho, Aurea; Madsen, Eirik; Ambrósio, António F.; Veruki, Margaret Lin; Hartveit, Espen (Peer reviewed; Journal article, 2015-09)There is increasing evidence that diabetic retinopathy is a primary neuropathological disorder that precedes the microvascular pathology associated with later stages of the disease. Recently, we found evidence for altered ... -
Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuit
Beltran Matas, Pablo; Hartveit, Espen; Veruki, Margaret Lin (Journal article; Peer reviewed, 2021)The NMDA receptors (NMDARs) expressed by AII and A17 amacrine cells, the two main inhibitory interneurons of the rod pathway microcircuit in the mammalian retina, are exclusively extrasynaptic, activated by ambient levels ... -
Differential contribution of gap junctions to the membrane properties of ON- and OFF-bipolar cells of the rat retina
Fournel, Rémi; Hartveit, Espen; Veruki, Margaret Lin (Journal article; Peer reviewed, 2021)Gap junctions are ubiquitous within the retina, but in general, it remains to be determined whether gap junction coupling between specific cell types is sufficiently strong to mediate functionally relevant coupling via ... -
Digital reconstruction and quantitative morphometric analysis of bipolar cells in live rat retinal slices
Fournel, Rémi; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)Bipolar cells convey signals from photoreceptors in the outer retina to amacrine and ganglion cells in the inner retina. In mammals, there are typically 10–15 types of cone bipolar cells and one type of rod bipolar cell. ... -
Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus
Castilho, Aurea; Ambrósio, António F.; Hartveit, Espen; Veruki, Margaret Lin (Peer reviewed; Journal article, 2015-04)Diabetes leads to dysfunction of the neural retina before and independent of classical microvascular diabetic retinopathy, but previous studies have failed to demonstrate which neurons and circuits are affected at the ... -
Electrical synapses between AII amacrine cells in the retina: Function and modulation
Hartveit, Espen; Veruki, Margaret Lin (Peer reviewed; Journal article, 2012)Adaptation enables the visual system to operate across a large range of background light intensities. There is evidence that one component of this adaptation is mediated by modulation of gap junctions functioning as ... -
Electrotonic signal processing in AII amacrine cells: compartmental models and passive membrane properties for a gap junction-coupled retinal neuron
Zandt, Bas-Jan; Veruki, Margaret Lin; Hartveit, Espen (Peer reviewed; Journal article, 2018-09)Amacrine cells are critical for processing of visual signals, but little is known about their electrotonic structure and passive membrane properties. AII amacrine cells are multifunctional interneurons in the mammalian ... -
Extrasynaptic NMDA receptors on rod pathway amacrine cells: molecular composition, activation, and signaling
Veruki, Margaret Lin; Zhou, Yifan; Castilho, Aurea; Morgans, Catherine W.; Hartveit, Espen (Peer reviewed; Journal article, 2019)In the rod pathway of the mammalian retina, axon terminals of glutamatergic rod bipolar cells are presynaptic to AII and A17 amacrine cells in the inner plexiform layer. Recent evidence suggests that both amacrines express ... -
Functional NMDA receptors are expressed by both AII and A17 amacrine cells in the rod pathway of the mammalian retina
Zhou, Yifan; Tencerova, Barbora; Hartveit, Espen; Veruki, Margaret Lin (Journal article, 2016-01)At many glutamatergic synapses, non-N-methyl-d-aspartate (NMDA) and NMDA receptors are coexpressed postsynaptically. In the mammalian retina, glutamatergic rod bipolar cells are presynaptic to two rod amacrine cells (AII ... -
Functional properties of GABAA receptors of AII amacrine cells of the rat retina
Beltran Matas, Pablo; Hartveit, Espen; Veruki, Margaret Lin (Journal article, 2023-04-05)Amacrine cells are a highly diverse group of inhibitory retinal interneurons that sculpt the responses of bipolar cells, ganglion cells, and other amacrine cells. They integrate excitatory inputs from bipolar cells and ... -
Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina
Beltran Matas, Pablo; Castilho, Aurea; Tencer, Barbora; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)Amacrine cells constitute a large and heterogeneous group of inhibitory interneurons in the retina. The A17 amacrine plays an important role for visual signalling in the rod pathway microcircuit of the mammalian retina. ... -
Morphological properties of the axon initial segment-like process of AII amacrine cells in the rat retina
Liu, Jian Hao; Singh, Jeet Bahadur; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2021)Signal processing within the retina is generally mediated by graded potentials, whereas output is conveyed by action potentials transmitted along optic nerve axons. Among retinal neurons, amacrine cells seem to be an ... -
The mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distribution
Liu, Jian Hao; Peter, David Olukoya; Guttormsen, Maren Sofie Faldalen; Hossain, Md Kaykobad; Gerking, Yola; Veruki, Margaret Lin; Hartveit, Espen (Journal article; Peer reviewed, 2022)The vertebrate retina contains a large number of different types of neurons that can be distinguished by their morphological properties. Assuming that no location should be without a contribution from the circuitry and ... -
Multiphoton excitation microscopy for the reconstructionand analysis of single neuron morphology
Hartveit, Espen; Zandt, Bas-Jan; Veruki, Margaret Lin (Neuromethods, Chapter; Peer reviewed, 2019)Neurons are the main cellular components of the circuits of the central nervous system (CNS). The dendritic and axonal morphology of individual neurons display marked variability between neurons in different regions of the ... -
Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal AII amacrine cells imaged with multi-photon excitation microscopy
Zandt, Bas-Jan; Losnegård, Are; Hodneland, Erlend; Veruki, Margaret Lin; Lundervold, Arvid; Hartveit, Espen (Peer reviewed; Journal article, 2017-03)Background: Accurate reconstruction of the morphology of single neurons is important for morphometric studies and for developing compartmental models. However, manual morphological reconstruction can be extremely time-consuming ...