• Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...
    • Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Kremer, Andreas E.; Kummen, Martin; Boberg, Kirsten Muri; Elferink, Ronald P. Oude; Karlsen, Tom Hemming; Beuers, Ulrich; Vesterhus, Mette; Hov, Johannes Espolin Roksund (Peer reviewed; Journal article, 2019-06-11)
      Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n=165) ...
    • Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation 

      Mousa, Omar Y; Juran, Brian D; McCauley, Bryan M.; Vesterhus, Mette; Folseraas, Trine; Turgeon, Coleman T.; Ali, Ahmad; Schlicht, Erik M; Atkinson, Elizabeth J; Hu, Chang; Harnois, Denise; Carey, Elizabeth J; Gossard, Andrea A; Oglesbee, Devin; Eaton, John E; LaRusso, Nicholas F.; Gores, Gregory J.; Karlsen, Tom Hemming; Lazaridis, Konstantinos N. (Journal article; Peer reviewed, 2020)
      Background and Aims: Altered bile acid (BA) homeostasis is an intrinsic facet of cholestatic liver diseases, but clinical usefulness of plasma BA assessment in primary sclerosing cholangitis (PSC) remains understudied. We ...
    • Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis 

      Dhillon, Amandeep Kaur; Kummen, Martin; Trøseid, Marius; Åkra, Sissel; Liaskou, Evaggelia; Moum, Bjørn; Vesterhus, Mette; Karlsen, Tom Hemming; Seljeflot, Ingebjørg; Hov, Johannes Espolin Roksund (Peer reviewed; Journal article, 2019-02)
      Background & Aims: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. We aimed to investigate whether ...
    • Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease 

      Vesterhus, Mette; Nielsen, Mette; Hov, Johannes Espolin Roksund; Saffioti, Francesca; Manon-Jensen, Tina; Leeming, Diana Julie; Moum, Bjørn; Boberg, Kirsten Muri; Pinzani, Massimo; Karlsen, Tom Hemming; Karsdal, Morten A; Thorburn, Douglas (Journal article; Peer reviewed, 2021)
      Background & Aims: Primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) are phenotypically distinct autoimmune liver diseases that progress to cirrhosis and liver failure; ...
    • Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study 

      de Vries, Elisabeth M.G.; Färkkilä, Martti; Milkiewicz, Piotr; Hov, Johannes Espolin Roksund; Eksteen, Bertus; Thorburn, Douglas; Chazouillères, Olivier; Pares, Albert; Nygård, Ståle; Gilja, Odd Helge; Wunsch, Ewa; Invernizzi, Pietro; Carbone, Marco; Bernuzzi, Francesca; Boberg, Kirsten Muri; Røsjø, Helge; Rosenberg, William; Beuers, Ulrich H.; Ponsioen, Cyriel Y.; Karlsen, Tom Hemming; Vesterhus, Mette (Peer reviewed; Journal article, 2017-10)
      Background & Aims: Biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC) have not been firmly established. Enhanced liver fibrosis (ELF) test was previously reported to predict outcome ...
    • Liver elastography in healthy children using three different systems - how many measurements are necessary? 

      Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland; Olafsdottir, Edda Jonina; Gilja, Odd Helge; Vesterhus, Mette (Journal article; Peer reviewed, 2020-12-21)
      Purpose Liver elastography is increasingly being applied in screening for and follow-up of pediatric liver disease, and has been shown to correlate well with fibrosis staging through liver biopsy. Because time is of the ...
    • Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems 

      Mjelle, Anders Batman; Fossdal, Guri; Gilja, Odd Helge; Vesterhus, Mette (Journal article; Peer reviewed, 2020)
      The aim of the study described here was to characterize three different liver elastography methods in primary sclerosing cholangitis (PSC) patients, for the first time exploring 2-D shear wave elastography (2-D-SWE) in PSC ...
    • Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man 

      Vesterhus, Mette (Doctoral thesis, 2009-12-04)
      Exocrine and endocrine pancreatic disease is often observed to occur together. The close colocalization of the endocrine and exocrine tissues within one organ, as well as their common embryological ancestry, have given ...
    • Normal Liver Stiffness Values in Children - A Comparison of Three Different Elastography Methods 

      Mjelle, Anders Batman; Mulabecirovic, Anesa; Havre, Roald Flesland; Rosendahl, Karen; Juliusson, Petur Benedikt; Olafsdottir, Edda Jonina; Gilja, Odd Helge; Vesterhus, Mette (Peer reviewed; Journal article, 2019-05)
      Objectives: Noninvasive tests for the evaluation of liver fibrosis are particularly helpful in children to avoid general anesthesia and potential complications of invasive tests. We aimed to establish reference values for ...
    • Point Shear Wave Elastography and the Effect of Physical Exercise, Alcohol Consumption, and Respiration in Healthy Adults 

      Taraldsen, Victoria; Tomasgard, Sunneva; Rudlang, Margrethe Thune; Gilja, Odd Helge; Vesterhus, Mette; Mjelle, Anders Batman (Journal article; Peer reviewed, 2020)
      Purpose Ultrasound elastography is a noninvasive method for liver stiffness measurement (LSM) with the aim of reflecting approximate liver fibrosis load. Despite minimal evidence, current guidelines recommend 10 min of ...
    • Reduced Pancreatic Volume in Hepatocyte Nuclear Factor 1A-Maturity-Onset Diabetes of the Young 

      Vesterhus, Mette; Haldorsen, Ingfrid S.; Ræder, Helge; Molven, Anders; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2008-09)
      Context: There are interplays between the endocrine and exocrine pancreas. Werecently reported an increased frequency of exocrine dysfunction in HNF1A-maturity-onset diabetes of the young (MODY3) patients, compared with ...
    • Second-line and Third-line therapy for Autoimmune Hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group 

      Lohse, Ansgar W.; Sebode, Marcial; Jørgensen, Marianne H.; Ytting, Henriette; Karlsen, Tom Hemming; Kelly, Deirdre; Manns, Michael P.; Vesterhus, Mette (Journal article; Peer reviewed, 2020)
      Most patients with autoimmune hepatitis respond well to standard immunosuppressive therapy with steroids and azathioprine, and while untreated disease is usually fatal, patients who respond well to therapy have an excellent ...