Browsing Bergen Open Research Archive by Author "Vintermyr, Olav Karsten"
Now showing items 1-20 of 20
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AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells
Lotsberg, Maria Lie; Wnuk-Lipinska, Katarzyna; Terry, Stéphane; Tan, Tuan Zea; Lu, Ning; Trachsel-Moncho, Laura; Røsland, Gro Vatne; Siraji, Muntequa Ishtiaq; Hellesøy, Monica; Rayford, Austin James; Jacobsen, Kirstine; Ditzel, Henrik J; Vintermyr, Olav Karsten; Bivona, Trever G; Minna, John; Brekken, Rolf A; Baguley, Bruce; Micklem, David; Akslen, Lars A.; Gausdal, Gro; Simonsen, Anne; Thiery, Jean Paul; Chouaib, Salem; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2020)Introduction Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine ... -
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
A Comparison of p53 Isoform Profiles and Apoptosis Induced by Camptothecin or a Herbal Khat Extract (Catha Edulis (Vahl) Forssk. ex Endl.) in Leukemic Cell Lines: Exploring Cellular Responses in Therapy Development
Onyango, Therese Bredholt; Hjelle, Sigrun Margrethe; Haaland, Ingvild; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2020)Khat (Catha edulis (Vahl) Forssk. ex Endl.) is habitually used as a natural stimulant by millions of people, but is associated with adverse effects on gastrointestinal, cardiovascular and central neural systems. At the ... -
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe; Sulen, André; Reikvam, Håkon; Aarstad, Hans Jørgen; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Bruserud, Øystein; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2013-07-11)Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is ... -
Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential
Dongre, Harsh; Rana, Neha; Fromreide, Siren; Rajthala, Saroj; Engelsen, Ingeborg Bøe; Paradis, Justine; Gutkind, J. Silvio; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Bjørge, Line; Costea, Daniela Elena (Journal article; Peer reviewed, 2020)Vulvar squamous cell carcinoma associated with lichen sclerosus (VLS-VSCC) are rare tumors but with higher recurrence and worse prognosis than other types of VSCC. Lack of experimental models has limited the search for ... -
Excellent response of intramedullary Erdheim-Chester disease to vemurafenib: a case report
Tzoulis, Charalampos; Schwarzlmüller, Thomas; Søfteland, Eirik; Neckelmann, Gesche; Biermann, Martin; Haroche, Julien; Straume, Oddbjørn; Gjerde, Ivar Otto; Vintermyr, Olav Karsten (Peer reviewed; Journal article, 2015-04-30)Background: Erdheim-Chester disease is a rare histiocytosis characterized by multi-systemic organ involvement. Immune-modulating agents such as interferon-alpha have limited success and the disorder is progressive and ... -
First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma
Helland, Øystein; Popa, Mihaela Lucia; Vintermyr, Olav Karsten; Molven, Anders; Gjertsen, Bjørn Tore; Bjørge, Line; McCormack, Emmet (Peer reviewed; Journal article, 2014-03-04)Purpose: Preclinical models of epithelial ovarian cancer have not been exploited to evaluate the clinical standard combination therapy of surgical debulking with follow-up chemotherapy. As surgery is critical to patient ... -
Granulocyte macrophage-colony stimulating factor and keratinocyte growth factor control of early stages of differentiation of oral epithelium
Das, Ridhima; Virlan, Maria Justina Roxana; Xenaki, Victoria; Kulasekara, Keerthi Kumara; Lukandu, Ochiba Mohammed; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Calenic, Bogdan; Costea, Daniela Elena (Journal article; Peer reviewed, 2022)Oral epithelial differentiation is known to be directed by underlying fibroblasts, but the responsible factor(s) have not been identified. We aimed here to identify fibroblast-derived factors responsible for oral epithelial ... -
Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report
Trovik, Linn; Sandnes, Miriam; Blomberg, Bjørn; Holmaas, Gunhild; Ahmed, Aymen B.; Tvedt, Tor Henrik Anderson; Vintermyr, Olav Karsten; Reikvam, Håkon (Journal article; Peer reviewed, 2020)Background Hemophagocytic lymphohistiocytosis (HLH) is a rare heterogenous genetic or acquired hyperinflammatory syndrome associated with a high degree of morbidity and mortality. HLH has clinical manifestations related ... -
HER2 expression patterns in paired primary and metastatic endometrial cancer lesions
Halle, Mari Kyllesø; Tangen, Ingvild Løberg; Berg, Hege Fredriksen; Hoivik, Erling A; Mauland, Karen Klepsland; Kusonmano, Kanthida; Berg, Anna; Hurtado, Antoni; Kalland, Karl-Henning; Øyan, Anne Margrete; Stefansson, Ingunn; Vintermyr, Olav Karsten; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Trovik, Jone; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2017-11-23)Background: Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) receptor in breast and gastric cancers, the potential of HER2 as a therapeutic target in other cancers ... -
HPV DNA testing improves CIN2+ risk stratification and detection of CIN2+ in delayed triage of ASCUS and LSIL. A population-based follow-up study from Western Norway
Budal, Elisabeth Berge; Haugland, Hans Kristian; Skar, Robert; Mæhle, Bjørn Ove; Bjørge, Tone; Vintermyr, Olav Karsten (Peer reviewed; Journal article, 2014-02)In Norway, Pap smears with atypical squamous cells of uncertain significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) are triaged after 6 months. The aim of the study was to evaluate effects of ... -
IGHV gene usage and mutational status in follicular lymphoma: Correlations with prognosis and patient age
Berget, Ellen; Molven, Anders; Løkeland, Turid; Helgeland, Lars; Vintermyr, Olav Karsten (Peer reviewed; Journal article, 2015-07)Follicular lymphoma (FL) is a heterogeneous disease with some patients developing progressively or transformed disease early, whereas others follow an indolent clinical course. We evaluated the prognostic value of ... -
In vitro-stimulated IL-6 monocyte secretion and in vivo peripheral blood T lymphocyte activation uniquely predicted 15-year survival in patients with head and neck squamous cell carcinoma
Aarstad, Helene Hersvik; Vintermyr, Olav Karsten; Ulvestad, Elling; Kross, Kenneth Wilfried; Heimdal, John-Helge; Aarstad, Hans Jørgen (Peer reviewed; Journal article, 2015-06-16)The study was performed in order to determine whether peripheral blood monocyte in vitro function, and lymphocyte in vivo activation at diagnosis, was associated with HPV tumor infection status and 15-year survival in head ... -
Olaparib monotherapy as primary treatment in unselected triple negative breast cancer
Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa; Llop-Guevara, Alba; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Vagstad, Geirfinn; Venizelos, Andreas; Minsaas, Laura; Leirvaag, Beryl; Gudlaugsson, Einar; Vintermyr, Olav Karsten; Aase, Hildegunn Siv; Aas, Turid; Balmaña, Judith; Serra, Violeta; Janssen, Emiel; Knappskog, Stian; Lønning, Per Eystein (Journal article; Peer reviewed, 2020)Background The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic ... -
Profiling and functional analysis of microRNA deregulation in cancer-associated fibroblasts in oral squamous cell carcinoma depicts an anti-invasive role of microRNA-204 via regulation of their motility
Rajthala, Saroj; Min, Anjie; Parajuli, Himalaya; Debnath, Kala Chand; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Vintermyr, Olav Karsten; Johannessen, Anne Christine; Sapkota, Dipak; Costea, Daniela Elena (Journal article; Peer reviewed, 2021-11-04)Background: Knowledge on the role of miR changes in tumor stroma for cancer progression is limited. This study aimed to investigate the role of miR dysregulation in cancer-associated fibroblasts (CAFs) in oral squamous ... -
Prognostic value of bone marrow involvement by clonal immunoglobulin gene rearrangements in follicular lymphoma
Berget, Ellen; Helgeland, Lars; Liseth, Knut; Løkeland, Turid; Molven, Anders; Vintermyr, Olav Karsten (Peer reviewed; Journal article, 2014-09-18)Aims: We aimed to evaluate the prognostic value of routine use of PCR amplification of immunoglobulin gene rearrangements in bone marrow (BM) staging in patients with follicular lymphoma (FL). Methods: Clonal rearrangements ... -
Randomized implementation of a primary human papillomavirus testing-based cervical cancer screening protocol for women 34 to 69 years in Norway
Nygård, Mari; Engesæter, Birgit Øvstebø; Castle, Philip E.; Berland, Jannicke; Eide, Maj Liv; Iversen, Ole-Erik; Jonassen, Christine M; Christiansen, Irene Kraus; Vintermyr, Olav Karsten; Trope, Ameli (Journal article; Peer reviewed, 2022)Background: Cervical cancer screening programs are facing a programmatic shift where screening protocol based on human papillomavirus testing (HPV-Screening protocol) is replacing the liquid-based cytology (LBC-Screening ... -
Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis
Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Ahmed, Aymen B; Vintermyr, Olav Karsten; Hervig, Tor Audun; Guttormsen, Anne Berit; Reikvam, Håkon (Journal article; Peer reviewed, 2021)Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused ... -
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters
Dongre, Harsh N.; Haave, Hilde; Fromreide, Siren; Erland, Fredrik Atteraas; Moe, Svein Erik Emblem; Dhayalan, Sophia Manueldas; Riis, Rasmus Kopperud; Sapkota, Dipak; Costea, Daniela Elena; Aarstad, Hans Jørgen; Vintermyr, Olav Karsten (Journal article; Peer reviewed, 2021)Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ... -
Tumor infiltration levels of CD3, Foxp3 (+) lymphocytes and CD68 macrophages at diagnosis predict 5-year disease-specific survival in patients with oropharynx squamous cell carcinoma
Ljøkjel, Borghild; Haave, Hilde; Lybak, Stein; Vintermyr, Olav Karsten; Helgeland, Lars; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2022)Head and neck cancer (HNC) is the sixth most common cancer worldwide. Oropharyngeal (OP) cancers are of special interest because of possible underlying HPV infection which is tied to prognosis. Influxes of inflammatory ...