Blar i Bergen Open Research Archive på forfatter "Wang, Shuai"
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Disulfiram, a ferroptosis inducer, triggers lysosomal membrane permeabilization by up-regulating ROS in glioblastoma
Qiu, Chen; Zhang, Xin; Huang, Bin; Wang, Shuai; Zhou, Wenjing; Li, Chao; Li, Xingang; Wang, Jian; Yang, Ning (Journal article; Peer reviewed, 2020)Introduction: Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and ... -
Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma
Han, Mingzhi; Wang, Shuai; Zhao, Wen-Bo; Ni, Shi-Lei; Yang, Ning; Kong, Yang; Huang, Bin; Chen, An-Jing; Li, Xin-Gang; Wang, Jian; Wang, Dong-Hai (Peer reviewed; Journal article, 2019)Background: Dysregulation of immune checkpoint molecules leads to immune evasion in human tumours but has become a viable target for tumour therapy. Here, we examined expression of Herpes virus entry mediator (HVEM), an ... -
Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling
Han, Mingzhi; Wang, Shuai; Fritah, Sabrina; Wang, Xu; Zhou, Wenjing; Yang, Ning; Ni, Shilei; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2020)Long non-coding RNAs play critical roles in tumour progression. Through analysis of publicly available genomic datasets, we found that MIR22HG, the host gene of microRNAs miR-22-3p and miR-22-5p, is ranked among the most ... -
The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma
Kong, Yang; Feng, Zichao; Chen, Anjing; Qi, Qichao; Han, Mingzhi; Wang, Shuai; Zhang, Yulin; Zhang, Xin; Yang, Ning; Wang, Jiwei; Huang, Bin; Zhang, Qing; Xiang, Guo; Li, Wenjie; Zhang, Di; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2019-09-27)Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the molecular basis for its ... -
Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma
Zhang, Xun; Yao, Zhong; Xue, Zhiyi; Wang, Shuai; Liu, Xuemeng; Hu, Yaotian; Zhang, Yan; Wang, Jian; Li, Xingang; Chen, Anjing (Journal article; Peer reviewed, 2022)Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying ... -
Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention
Wang, Xu; Han, Mingzhi; Wang, Shuai; Sun, Yanfei; Zhao, Wenbo; Xue, Zhiyi; Liang, Xiangjun; Huang, Bin; Li, Gang; Chen, Anjing; Li, Xingang; Wang, Jian (Journal article; Peer reviewed, 2022)Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential molecular targets for cancer therapy. Here, ... -
Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma
Han, Mingzhi; Wang, Shuai; Yang, Ning; Wang, Xu; Zhao, Wenbo; Sdik Saed, Halala; Daubon, Thomas; Huang, Bin; Chen, Anjing; Li, Gang; Miletic, Hrvoje; Thorsen, Frits; Bjerkvig, Rolf; Li, Xingang; Wang, Jian (Peer reviewed; Journal article, 2019-11-28)Dysregulated cholesterol metabolism is a hallmark of many cancers, including glioblastoma (GBM), but its role in disease progression is not well understood. Here, we identified cholesterol 24‐hydroxylase (CYP46A1), a ... -
Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib
Yao, Zhong; Zhang, Xun; Zhao, Feihu; Wang, Shuai; Chen, Anjing; Huang, Bin; Wang, Jian; Li, Xingang (Journal article; Peer reviewed, 2020)Ursodeoxycholic acid (UDCA) has demonstrated cancer suppressive potential in several tumors. Here, we investigated the antitumor potential and biochemical mechanism of UDCA on glioblastoma multiforme (GBM), the deadliest ...