Browsing Bergen Open Research Archive by Author "Watne, Leiv"

Now showing items 1-5 of 5

    • Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease 

      Knapskog, Anne Brita; Aksnes, Mari; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Saltvedt, Ingvild Tina; Giil, Lasse Melvær; Watne, Leiv (Journal article; Peer reviewed, 2023)
      Introduction: The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a possible ...

    • Impaired glucose utilization in the brain of patients with delirium following hip fracture 

      Titlestad, Irit; Watne, Leiv; Caplan, Gideon A.; McCann, Adrian; Ueland, Per Magne; Neerland, Bjørn Erik; Myrstad, Marius; Halaas, Nathalie Bodd; Pollmann, Christian Thomas; Henjum, Kristi; Ranhoff, Anette Hylen; Solberg, Lene Bergendal; Figved, Wender; Cunningham, Colm; Melvær, Giil Lasse (Journal article; Peer reviewed, 2024)
      Alterations in brain energy metabolism have long been proposed as one of several neurobiological processes contributing to delirium. This is supported by previous findings of altered CSF lactate and neuron-specific enolase ...

    • Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging 

      Solvang, Stein-Erik Hafstad; Hodge, Allison; Watne, Leiv; Cabral-Marques, Otavio; Nordrehaug, Jan Erik; Giles, Graham G.; Dugué, Pierre-Antoine; Nygård, Ottar Kjell; Ueland, Per Magne; McCann, Adrian; Idland, Ane-Victoria; Midttun, Øivind; Ulvik, Arve; Halaas, Nathalie Bodd; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2022)
      The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ...

    • Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies 

      Wang, Heling; Siow, Richard; Schmauck-Medina, Tomás Alejandro; Zhang, Jianying; Sandset, Per Morten; Filshie, Clare; Lund, Øystein; Partridge, Linda; Bergersen, Linda Hildegard; Juel Rasmussen, Lene; Palikaras, Konstantinos; Sotiropoulos, Ioannis; Storm-Mathisen, Jon; Rubinsztein, David C.; Spillantini, Maria Grazia; De Zeeuw, Chris I.; Watne, Leiv; Vyhnalek, Martin; Veverova, Katerina; Liang, Xiao; Tavernarakis, Nektarios; Bohr, Vilhelm A.; Yokote, Koutaro; Saarela, Janna Saija; Nilsen, Hilde; Gonos, Efstathios S.; Scheibye-Knudsen, Morten; Chen, Guobing; Kato, Hisaya; Selbæk, Geir; Fladby, Tormod; Nilsson, Per; Simonsen, Anne Gjøen; Aarsland, Dag; Hindkjær Lautrup, Sofie; Ottersen, Ole Petter; Cox, Lynne S.; Fang, Fei (Journal article; Peer reviewed, 2024)
      Unhealthy aging poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the aging process offers a promising approach to reduce the burden of a number of age-related diseases, such ...

    • Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease 

      Knapskog, Anne-Brita; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Solvang, Stein-Erik Hafstad; Saltvedt, Ingvild Tina; Watne, Leiv; Aksnes, Mari (Journal article; Peer reviewed, 2024-07-27)
      Background: Sex differences in neuroinflammation could contribute to women’s increased risk of Alzheimer’s disease (AD), providing rationale for exploring sex-specific AD biomarkers. In AD, dysregulation of the kynurenine ...