Browsing Bergen Open Research Archive by Author "Watson, Martin M"
Now showing items 1-5 of 5
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Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis
Søreide, Kjetil; Watson, Martin M; Lea, Dordi; Nordgård, Oddmund; Søreide, Jon Arne; Hagland, Hanne R (Peer reviewed; Journal article, 2016-06-29)Background: More accurate predictive and prognostic biomarkers for patients with colorectal cancer (CRC) primaries or colorectal liver metastasis (CLM) are needed. Outside clinical trials, the translational integration of ... -
Elevated microsatellite alterations at selected tetranucleotides (EMAST) is not attributed to MSH3 loss in stage I-III colon cancer: An automated, digitalized assessment by immunohistochemistry of whole slides and hot spots
Watson, Martin M; Lea, Dordi; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2019-12)INTRODUCTION: EMAST is a poorly understood form of microsatellite instability (MSI) in colorectal cancer (CRC) for which loss of MSH3 has been proposed as the underlying mechanism, based on experimental studies. We aimed ... -
Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?
Watson, Martin M; Lea, Dordi; Rewcastle, Emma; Hagland, Hanne Røland; Søreide, Kjetil (Peer reviewed; Journal article, 2016-07)Microsatellite instability (MSI) is associated with better prognosis in colorectal cancer (CRC). Elevated microsatellite alterations at selected tetranucleotides (EMAST) is a less-understood form of MSI. Here, we aim to ... -
Microsatellite instability at tetranucleotides (EMAST) in colorectal cancer: clinical relevance, mechanisms and immune markers
Watson, Martin M (Doctoral thesis, 2020-06-18)Colorectal cancer (CRC) is the second-leading cause of cancer-related death and a global burden in terms of incidence, person-years of life lost and public health costs. About 10-20% of sporadic CRCs develop through a ... -
Prevalence and implications of elevated microsatellite alterations at selected tetranucleotides in cancer
Watson, Martin M; Berg, Marianne; Søreide, Kjetil (Peer reviewed; Journal article, 2014-04-01)Elevated microsatellite alterations at selected tetranucleotides (EMAST), a variation of microsatellite instability (MSI), has been reported in a variety of malignancies (e.g., neoplasias of the lung, head and neck, ...