Browsing Bergen Open Research Archive by Author "Wibrand, Karin"

Now showing items 1-8 of 8

    • The Arc of synaptic memory 

      Bramham, Clive R.; Alme, Maria N.; Bittins, Margarethe; Kuipers, Sjoukje D.; Nair, Rajeevkumar R.; Pai, Balagopal; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian; Wibrand, Karin (Peer reviewed; Journal article, 2010)
      The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ...

    • Common variants in the ARC gene are not associated with cognitive abilities 

      Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Peer reviewed; Journal article, 2015-09-03)
      Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ...

    • Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity 

      Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida; Patil, Sudarshan; Kaczorowski, Dominik C.; Bramham, Clive R.; Dinger, Marcel E.; Wibrand, Karin (Peer reviewed; Journal article, 2015-10-01)
      Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene transcription is known to be required in the formation of stable LTP, the ...

    • Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats 

      Wibrand, Karin; Berge, Kjetil; Messaoudi, Michaël; Duffaud, Anaïs; Panja, Debabrata; Bramham, Clive R.; Burri, Lena (Peer reviewed; Journal article, 2013-01-25)
      Background: The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats. Methods: Cognition was assessed using the Aversive Light Stimulus Avoidance Test (ALSAT). ...

    • MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc 

      Wibrand, Karin; Pai, Balagopal; Siripornmongcolchai, Taweeporn; Bittins, Margarethe; Berentsen, Birgitte; Ofte, May Lillian; Weigel, Arwed; Skaftnesmo, Kai Ove; Bramham, Clive R. (Peer reviewed; Journal article, 2012-07-26)
      Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types of experience-dependent synaptic plasticity and long-term memory in mammals. However, the mechanisms governing Arc-specific ...

    • NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo 

      Pai, Balagopal; Siripornmongcolchai, Taweeporn; Berentsen, Birgitte; Pakzad, Ashraf; Vieuille, Christel Marie; Pallesen, Ståle; Pajak, Maciej; Simpson, T. Ian; Armstrong, J. Douglas; Wibrand, Karin; Bramham, Clive R. (Peer reviewed; Journal article, 2014-01-13)
      microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A major goal is to identify changes in miRNA expression underlying protein synthesis-dependent forms of synaptic plasticity such as long-term ...

    • Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK 

      Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. (Peer reviewed; Journal article, 2014-11-20)
      BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ...

    • Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. 

      Maag, Jesper L.V.; Kaczorowski, Dominik C.; Panja, Debabrata; Peters, Timothy J.; Bramham, Clive R.; Wibrand, Karin; Dinger, Marcel E. (Peer reviewed; Journal article, 2017-03-23)
      Background: DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not ...