• Influence of p53 isoform expression on survival in high-grade serous ovarian cancers 

      Bischof, Katharina; Knappskog, Stian; Hjelle, Sigrun Margrethe; Stefansson, Ingunn; Woie, Kathrine; Salvesen, Helga; Gjertsen, Bjørn Tore; Bjørge, Line (Peer reviewed; Journal article, 2019-03-27)
      High-grade serous ovarian carcinoma (HGSOC) is characterised by alterations in the p53 pathway. The expression levels of p53 isoforms have been shown to be associated with patient survival in several cancers. This study ...
    • Late-week surgical treatment of endometrial cancer is associated with worse long-term outcome: Results from a prospective, multicenter study 

      Njølstad, Tormund Salvesen; Werner, Henrica Maria Johanna; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Oddenes, Klaus; Bjørge, Line; Engh, Marie Ellström; Woie, Kathrine; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Salvesen, Helga; Trovik, Jone (Peer reviewed; Journal article, 2017-08-03)
      Surgery is the cornerstone in primary endometrial cancer treatment, and with curative intent it constitutes total hysterectomy and bilateral salpingo-oopherectomy. In addition, lymphadenectomy is performed in selected ...
    • Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer 

      Forsse, David Erik; Berg, Hege Fredriksen; Bozickovic, Olivera; Engerud, Hilde Renate; Halle, Mari Kyllesø; Høivik, Erling Andre; Woie, Kathrine; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2020)
      Objective Main controversies in endometrial cancer treatment include the role of lymphadenectomy and optimal adjuvant treatment. We assessed clinical outcome in a population-based endometrial cancer cohort in relation to ...
    • A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue 

      Haslene-Hox, Hanne; Oveland, Eystein; Berg, Kaja Christine Graue; Kolmannskog, Odd; Woie, Kathrine; Salvesen, Helga Birgitte; Tenstad, Olav; Wiig, Helge (Peer reviewed; Journal article, 2011-04-26)
      Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ...
    • Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood 

      Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga Birgitte; Wiig, Helge; Tenstad, Olav (Peer reviewed; Journal article, 2014-12)
      Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ...
    • Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer 

      Berg, Anna; Fasmer, Kristine Eldevik; Mauland, Karen Klepsland; Ytre-Hauge, Sigmund; Høivik, Erling Andre; Husby, Jenny Hild Aase; Tangen, Ingvild Løberg; Trovik, Jone; Halle, Mari Kyllesø; Woie, Kathrine; Bjørge, Line; Bjørnerud, Atle; Salvesen, Helga; Werner, Henrica Maria Johanna; Krakstad, Camilla; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2016-09-13)
      Hypoxia is frequent in solid tumors and linked to aggressive phenotypes and therapy resistance. We explored expression patterns of the proposed hypoxia marker HIF-1α in endometrial cancer (EC) and investigate whether ...