Blar i Bergen Open Research Archive på forfatter "Xing, Zhe"
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Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect
Sharma, Sunita; Xue, Ying; Xing, Zhe; Yassin, Mohammed Ahmed; Sun, Yang; Lorens, James; Finne-Wistrand, Anna; Sapkota, Dipak; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2019-04-11)Apart from osteogenesis, neovascularization of the defect area is an important determinant for successful bone healing. Accordingly, several studies have employed the combined delivery of VEGFA and BMP2 for bone regeneration. ... -
Altered surface hydrophilicity on copolymer scaffolds stimulate the osteogenic differentiation of human mesenchymal stem cells
Xing, Zhe; Cai, Jiazheng; Sun, Yang; Cao, Mengnan; Li, Yi; Xue, Ying; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2020)Background: Recent studies have suggested that both poly(l-lactide-co-1,5-dioxepan-2-one) (or poly(LLA-co-DXO)) and poly(l-lactide-co-ε-caprolactone) (or poly(LLA-co-CL)) porous scaffolds are good candidates for use as ... -
Biological responses of dental pulp cells to surfaces modified by collagen 1 and fibronectin
Omer, A; Al-sharabi, Niyaz Abdulbaqi; Qiu, Y; Li, Y; Fujio, Masahito; Mustafa, Kamal Babikeir Eln; Xing, Zhe (Journal article; Peer reviewed, 2020)Collagen 1 (COL1) and fibronectin (FN) are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp cells (DPCs). The purpose of this study was to investigate the effect of COL1 ... -
Cell seeding density is a critical determinant for copolymer scaffolds-induced bone regeneration
Yassin, Mohammed Ahmed; Leknes, Knut N.; Pedersen, Torbjørn Østvik; Xing, Zhe; Sun, Yang; Lie, Stein Atle; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2015-11)Constructs intended for bone tissue engineering (TE) are influenced by the initial cell seeding density. Therefore, the objective of this study was to determine the effect of bone marrow stromal stem cells (BMSCs) density ... -
Conditioned media from hypoxic-cultured human dental pulp cells promotes bone healing during distraction osteogenesis
Fujio, Masahito; Xing, Zhe; Al-Sharabi, Niyaz; Xue, Ying; Yamamoto, Akihito; Hibi, Hideharu; Ueda, Minoru; Fristad, Inge; Mustafa, Kamal (Peer reviewed; Journal article, 2015-11-27)Distraction osteogenesis (DO) is a surgical procedure used to correct various skeletal disorders. Improving the technique by reducing the healing time would be of clinical relevance. The aim of this study was to determine ... -
Delivery of the Sox9 gene promotes chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells in an in vitro model
Wang, Zhenghui; Li, Xiaoli; He, Xijing; Wu, Baojun; Xu, Min; Chang, Huimin; Zhang, Xianghong; Xing, Zhe; Jing, Xiaohong; Kong, Demin; Kou, Xiaohui; Yang, Y.Y. (Peer reviewed; Journal article, 2014-04)SRY-related high-mobility-group box 9 (Sox9) gene is a cartilage-specific transcription factor that plays essential roles in chondrocyte differentiation and cartilage formation. The aim of this study was to investigate the ... -
Endochondral Ossification Induced by Cell Transplantation of Endothelial Cells and Bone Marrow Stromal Cells with Copolymer Scaffold Using a Rat Calvarial Defect Model
Xing, Zhe; Jiang, Xiaofeng; Si, Qingzong; Finne-Wistrand, Anna; Liu, Bin; Xue, Ying; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)It has been recently reported that, in a rat calvarial defect model, adding endothelial cells (ECs) to a culture of bone marrow stromal cells (BMSCs) significantly enhanced bone formation. The aim of this study is to further ... -
Endothelial cells influence the osteogenic potential of bone marrow stromal cells
Xue, Ying; Xing, Zhe; Hellem, Sølve; Arvidson, Kristina Fyrberg; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2009-11-17)Background: Improved understanding of the interactions between bone cells and endothelial cells involved in osteogenesis should aid the development of new strategies for bone tissue engineering. The aim of the present study ... -
Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs
Pedersen, Torbjørn Østvik; Blois, Anna L; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James B.; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2013-05-17)Introduction: A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic ... -
Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation
Pedersen, Torbjørn Østvik; Blois, Anna L; Xue, Ying; Xing, Zhe; Sun, Yang; Finne-Wistrand, Anna; Lorens, James B.; Fristad, Inge; Leknes, Knut N.; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2014-02-17)Introduction: Rapid establishment of functional blood vessels is a prerequisite for successful tissue engineering. During vascular development, endothelial cells (ECs) and perivascular cells assemble into a complex regulating ... -
Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo
Suliman, Salwa; Xing, Zhe; Wu, X; Xue, Ying; Pedersen, Torbjørn Østvik; Sun, Y; Døskeland, Anne Marie Simonne; Nickel, Joachim; Waag, Thilo; Lygre, Henning; Finne Wistrand, Anna; Steinmüller-Nethl, Doris; Krueger, Anke; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2015-01-10)A low dose of 1 μg rhBMP-2 was immobilised by four different functionalising techniques on recently developed poly(l-lactide)-co-(ε-caprolactone) [(poly(LLA-co-CL)] scaffolds. It was either (i) physisorbed on unmodified ...