Browsing Bergen Open Research Archive by Author "Xu, Ran"

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PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1

Ji, Jianxiong; Ding, Kaikai; Luo, Tao; Xu, Ran; Zhang, Xin; Huang, Bin; Chen, An-Jing; Zhang, Di; Miletic, Hrvoje; Bjerkvig, Rolf; Thorsen, Frits; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2019)

The Hippo signaling pathway controls organ development and is also known, in cancer, to have a tumor suppressing role. Within the Hippo pathway, we here demonstrate, in human gliomas, a functional interaction of a transmembrane ...
Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination

Zhang, Xin; Xu, Ran; Zhang, Chao; Xu, Yangyang; Han, Mingzhi; Huang, Bin; Chen, Anjing; Qiu, Chen; Thorsen, Frits; Prestegarden, Lars; Bjerkvig, Rolf; Wang, Jian; Li, Xingang (Peer reviewed; Journal article, 2017-09-05)

Background: Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid ...