Blar i Bergen Open Research Archive på forfatter "Xue, Zhiyi"

Viser treff 1-7 av 7

    • The dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions 

      Xue, Zhiyi; Zhang, Yan; Zhao, Ruiqi; Liu, Xiaofei; Grützmann, Konrad; Klink, Barbara; Zhang, Xun; Wang, Shuai; Zhao, Wenbo; Sun, Yanfei; Han, Mingzhi; Wang, Xu; Hu, Yaotian; Liu, Xuemeng; Yang, Ning; Qiu, Chen; Li, Wenjie; Huang, Bin; Li, Xingang; Bjerkvig, Rolf; Wang, Jian; Zhou, Wenjing (Journal article; Peer reviewed, 2024)
      Background Extensive local invasion of glioblastoma (GBM) cells within the central nervous system (CNS) is one factor that severely limits current treatments. The aim of this study was to uncover genes involved in the ...

    • HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells 

      Zhao, Wenbo; Wu, Yibo; Wang, Shuai; Zhao, Feihu; Liu, Wenyu; Xue, Zhiyi; Zhang, Lin; Wang, Jian; Han, Mingzhi; Li, Xingang; Huang, Bin (Journal article; Peer reviewed, 2024)
      Background The infiltrative nature of human gliomas renders complete surgical removal of tumors futile. Thus, illuminating mechanisms of their infiltrative properties may improve therapies and outcomes of glioma ...

    • Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma 

      Zhang, Xun; Yao, Zhong; Xue, Zhiyi; Wang, Shuai; Liu, Xuemeng; Hu, Yaotian; Zhang, Yan; Wang, Jian; Li, Xingang; Chen, Anjing (Journal article; Peer reviewed, 2022)
      Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying ...

    • Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention 

      Wang, Xu; Han, Mingzhi; Wang, Shuai; Sun, Yanfei; Zhao, Wenbo; Xue, Zhiyi; Liang, Xiangjun; Huang, Bin; Li, Gang; Chen, Anjing; Li, Xingang; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential molecular targets for cancer therapy. Here, ...

    • Thiabendazole Inhibits Glioblastoma Cell Proliferation and Invasion Targeting Mini-chromosome Maintenance Protein 2 

      Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Feng, Zichao; Zhang, Yulin; Liu, Xiaofei; Li, Wenjie; Zhang, Qing; Chen, Anjing; Huang, Bin; Wang, Jian (Journal article; Peer reviewed, 2022)
      Thiabendazole (TBZ), approved by the US Food and Drug Administration (FDA) for human oral use, elicits a potential anticancer activity on cancer cells in vitro and in animal models. Here, we evaluated the efficacy of TBZ ...

    • TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein 

      Yang, Xu; Zhang, Yan; Xue, Zhiwei; Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Liu, Guowei; Li, Wenjie; Liu, Xiaofei; Li, Xingang; Han, Mingzhi; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins ...

    • Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway 

      Liu, Xuemeng; Hu, Yaotian; Xue, Zhiyi; Zhang, Xun; Liu, Xiaofei; Liu, Guowei; Wen, Muzi; Chen, Anjing; Huang, Bin; Li, Xingang; Yang, Ning; Wang, Jian (Journal article; Peer reviewed, 2023)
      Background Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a ...