Blar i Bergen Open Research Archive på forfatter "Ytre-Hauge, Kristian Smeland"
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A case-control study of linear energy transfer and relative biological effectiveness related to symptomatic brainstem toxicity following pediatric proton therapy
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland; Lassen-Ramshad, Yasmin; Muren, Ludvig Paul; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2022)Background and purpose A fixed relative biological effectiveness (RBE) of 1.1 (RBE1.1) is used clinically in proton therapy even though the RBE varies with properties such as dose level and linear energy transfer (LET). ... -
Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET
Henjum, Helge; Dahle, Tordis Johnsen; Mairani, Andrea; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Boer, Camilla Grindeland; Redalen, Kathrine Røe; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)Introduction Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well-oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton ... -
Effect of an optimized X-ray blanket design on operator radiation dose in cardiac catheterization based on real-world angiography
Davidsen, Cedric; Bolstad, Kirsten Hansine Helene Nygaard; Ytre-Hauge, Kristian Smeland; Samnøy, Andreas Tefre; Vikenes, Kjell; Tuseth, Vegard (Journal article; Peer reviewed, 2022)Background There is increasing concern and focus in the interventional cardiology community on potential long term health issues related to radiation exposure and heavy wearable protection. Optimized shielding measures ... -
Efficacy and User Experience of a Novel X-Ray Shield on Operator Radiation Exposure during Cardiac Catheterization: A Randomized Controlled Trial
Davidsen, Cedric; Ytre-Hauge, Kristian Smeland; Samnøy, Andreas Tefre; Vikenes, Kjell; Lancellotti, Patrizio; Tuseth, Vegard (Journal article; Peer reviewed, 2023)BACKGROUND: Radiation shielding is mandatory during cardiac catheterization, but there is a need to improve efficacy and ease of use. METHODS: The aim of the study was to assess the shielding effect and user feedback ... -
A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy
Meric, Ilker; Alagoz, Enver; Hysing, Liv Bolstad; Kögler, Toni; Lathouwers, Danny; Lionheart, William R. B.; Mattingly, John; Obhodas, Jasmina; Pausch, Guntram; Pettersen, Helge Egil Seime; Ratliff, Hunter Nathaniel; Rovituso, Marta; Schellhammer, Sonja M.; Setterdahl, Lena Marie; Skjerdal, Kyrre; Sterpin, Edmond; Sudac, Davorin; Turko, Joseph A.; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting ... -
Hypoxia adapted relative biological effectiveness models for proton therapy: a simulation study
Garrido Hernandez, Guillermo; Henjum, Helge; Høiskar, Marte Kåstad; Dahle, Tordis Johnsen; Redalen, Kathrine; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2022)In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied although the RBE has been shown to depend on factors including the Linear Energy Transfer (LET). The biological effectiveness ... -
Image Reconstruction for Proton Therapy Range Verification via U-NETs
Setterdahl, Lena Marie; Lionheart, William R. B.; Holman, Sean F.; Skjerdal, Kyrre; Ratliff, Hunter Nathaniel; Ytre-Hauge, Kristian Smeland; Lathouwers, Danny; Meric, Ilker (Journal article; Peer reviewed, 2024)This study aims to investigate the capability of U-Nets in improving image reconstruction accuracy for proton range verification within the framework of the NOVO (Next generation imaging for real-time dose verification ... -
Influence of beam pruning techniques on LET and RBE in proton arc therapy
Henjum, Helge; Tjelta, Johannes; Fjæra, Lars Fredrik; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Lyngholm, Erlend; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)Introduction: Proton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk. We aimed to investigate if pruning ... -
Linear energy transfer-inclusive models of brainstem necrosis following proton therapy of paediatric ependymoma
Handeland, Andreas Havsgård; Indelicato, Daniel J.; Fjæra, Lars Fredrik; Ytre-Hauge, Kristian Smeland; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2023)Background and Purpose Radiation-induced brainstem necrosis after proton therapy is a severe toxicity with potential association to uncertainties in the proton relative biological effectiveness (RBE). A constant RBE of ... -
The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy
Henjum, Helge; Dahle, Tordis Johnsen; Fjæra, Lars Fredrik; Rørvik, Eivind; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla H.; Mairani, Andrea; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2021)Purpose: Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological ... -
Prompt gamma-ray spectroscopy in conjunction with the Monte Carlo Library Least Squares approach: applications to range verification in proton therapy
Skjerdal, Kyrre; Kögler, Toni; Lionheart, William; Ytre-Hauge, Kristian Smeland; Meric, Ilker (Journal article; Peer reviewed, 2023)Prompt Gamma-ray Spectroscopy (PGS) in conjunction with the Monte Carlo Library Least Squares (MCLLS) approach was investigated for the purposes of range monitoring in proton therapy through Monte Carlo simulations. Prompt ... -
A systematic approach for calibrating a Monte Carlo code to a treatment planning system for obtaining dose, LET, variable proton RBE and out-of-field dose
Tjelta, Johannes; Fjæra, Lars Fredrik; Ytre-Hauge, Kristian Smeland; Boer, Camilla Grindeland; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2023)Objective. While integration of variable relative biological effectiveness (RBE) has not reached full clinical implementation, the importance of having the ability to recalculate proton treatment plans in a flexible, ...