Browsing Bergen Open Research Archive by Author "Ytre-Hauge, Kristian"
Now showing items 1-10 of 10
-
The experimental dose ranges influence the LET_d dependency of the proton minimum RBE (RBE_min)
Rørvik, Eivind; Thørnqvist, Sara; Ytre-Hauge, Kristian (Peer reviewed; Journal article, 2019-09-23)Cell experiments have shown the proton relative biological effectiveness (RBE) to vary with dose and linear energy transfer (LET), which has led to development of variable RBE models. The RBE is normally estimated from two ... -
The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
Dahle, Tordis Johnsen; Rusten, Espen; Stokkevåg, Camilla Hanquist; Silvoniemi, Antti; Mairani, Andrea; Fjæra, Lars Fredrik; Rørvik, Eivind; Henjum, Helge; Wright, Pauliina; Boer, Camilla Grindeland; Forsback, Sarita; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)Introduction The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of ... -
Implementation of a double scattering nozzle for Monte Carlo recalculation of proton plans with variable relative biological effectiveness
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Stokkevåg, Camilla Hanquist; Muren, Ludvig Paul; Hsi, Wen C.; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)A constant relative biological effectiveness (RBE) of 1.1 is currently used in clinical proton therapy. However, the RBE varies with factors such as dose level, linear energy transfer (LET) and tissue type. Multiple RBE ... -
Inter-patient variations in relative biological efectiveness for craniospinal irradiation with protons
Ytre-Hauge, Kristian; Fjæra, Lars Fredrik; Rørvik, Eivind; Dahle, Tordis Johnsen; Dale, Jon Espen; Pilskog, Sara; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2020)Cranio-spinal irradiation (CSI) using protons has dosimetric advantages compared to photons and is expected to reduce risk of adverse effects. The proton relative biological effectiveness (RBE) varies with linear energy ... -
Measurement of Neutron Doses from Radiotherapy with 12C Ions and Photons
Ytre-Hauge, Kristian (Master thesis, 2009-05-21)The overall objective of this thesis has been to investigate the neutron doses from radiotherapy with photons and ions. The advantages of proton and ion therapy, compared to the use of photons were also examined. During ... -
Microdosimetry with a 3D silicon on insulator (SOI) detector in a low energy proton beamline
Samnøy, Andreas Tefre; Ytre-Hauge, Kristian; Malinen, Eirik; Tran, Linh; Rosenfeld, Anatoly; Povoli, Marco; Kok, Angela Chun Ying; Summanwar, Anand; Røhrich, Dieter (Journal article; Peer reviewed, 2020)An accurate description of the radiation quality of proton beams is a precondition to increase our understanding of radiobiological mechanisms and to develop accurate biological response models for radiotherapy. However, ... -
A Monte Carlo feasibility study for neutron based real-time range verification in proton therapy
Ytre-Hauge, Kristian; Skjerdal, Kyrre; Mattingly, John; Meric, Ilker (Peer reviewed; Journal article, 2019-02-14)Uncertainties in the proton range in tissue during proton therapy limit the precision in treatment delivery. These uncertainties result in expanded treatment margins, thereby increasing radiation dose to healthy tissue. ... -
Plan Selection in Proton Therapy of Locally Advanced Prostate Cancer with Simultaneous Treatment of Multiple Targets
Abal, Bonny; Øvrelid, Kaja Slåtsve; Engeseth, Grete May; Ytre-Hauge, Kristian; Hysing, Liv Bolstad; Pilskog, Sara (Journal article; Peer reviewed, 2020)Purpose Intensity modulated proton therapy (IMPT) of locally advanced prostate cancer can spare the bowel considerably compared with modern photon therapy, but simultaneous treatment of the prostate (p), seminal vesicles ... -
Spatial Agreement of Brainstem Dose Distributions Depending on Biological Model in Proton Therapy for Pediatric Brain Tumors
Fjæra, Lars Fredrik; Indelicato, Daniel J.; Ytre-Hauge, Kristian; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Toussaint, Laura; Dahl, Olav; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)Purpose During radiation therapy for pediatric brain tumors, the brainstem is a critical organ at risk, possibly with different radio-sensitivity across its substructures. In proton therapy, treatment planning is currently ... -
Variation in relative biological effectiveness for cognitive structures in proton therapy of pediatric brain tumors
Otterlei, Ole Marius; Indelicato, Daniel J.; Toussaint, Laura; Ytre-Hauge, Kristian; Pilskog, Sara; Fjæra, Lars Fredrik; Rørvik, Eivind; Pettersen, Helge Egil Seime; Muren, Ludvig Paul; Lassen-Ramshad, Yasmin; Di Pinto, Marcos; Stokkevåg, Camilla Hanquist (Journal article; Peer reviewed, 2021)Background Clinically, a constant value of 1.1 is used for the relative biological effectiveness (RBE) of protons, whereas in vitro the RBE has been shown to vary depending on physical dose, tissue type, and linear energy ...