• Clinical impact of changes in mitral regurgitation severity after medical therapy optimization in heart failure 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Inciardi, Riccardo M.; Lang, Chim C.; Lombardi, Carlo; Ng, Leong L.; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Background: Few data are available regarding changes in mitral regurgitation (MR) severity with guideline-recommended medical therapy (GRMT) in heart failure (HF). Our aim was to evaluate the evolution and impact of MR ...
    • Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Ponikowski, Piotr; Ravera, Alice; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2021)
      Aims Few data regarding the prevalence and prognostic impact of mitral regurgitation (MR) in patients with worsening chronic or new-onset acute heart failure (HF) are available. We investigated the role of MR in the BIOlogy ...
    • Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction 

      Woolley, Rebecca J.; Ceelen, Daan; Ouwerkerk, Wouter; Tromp, Jasper; Figarska, Sylwia M.; Anker, Stefan D.; Dickstein, Kenneth; Filippatos, Gerasimos; Zannad, Faiez; Marco, Metra; Ng, Leong L.; Samani, Nilesh J.; van Veldhuisen, Dirk J; Lang, Chim C.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of patients with HFpEF. We aimed to identify distinct pathophysiologic ...
    • Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure 

      Kobayashi, Masatake; Voors, Adriaan A.; Ouwerkerk, Wouter; Duarte, Kevin; Girerd, Nicolas; Rossignol, Patrick; Metra, Marco; Lang, Chim C.; Ng, Leong L.; Filippatos, Gerasimos; Dickstein, Kenneth; van Veldhuisen, Dirk J.; Zannad, Faiez; Ferreira, João Pedro (Journal article; Peer reviewed, 2021)
      Background Achieving target doses of angiotensin-converting-enzyme inhibitor/angiotensin-receptor blockers (ACEi/ARB) and beta-blockers in heart failure with reduced ejection fraction (HFrEF) is often underperformed. In ...
    • Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire 

      Ravera, Alice; Santema, Bernadet T.; Sama, Iziah E.; Meyer, Sven; Lombardi, Carlo; Carubelli, Valentina; Ferreira, João Pedro; Lang, Chim C.; Dickstein, Kenneth; Anker, Stefan D.; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Teerlink, John R.; Metra, Marco; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ-5D), and to ...
    • The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure 

      Pandhi, Paloma; Streng, Koen W.; Anker, Stefan D.; Cleland, John G.; Damman, Kevin; Dickstein, Kenneth; Pellicori, Pierpaolo; Lang, Chim C.; Ng, Leong; Samani, Nilesh J.; Zannad, Faiez; Metra, Marco; Rossignol, Patrick; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Voors, Adriaan A.; ter Maaten, Jozine M. (Journal article; Peer reviewed, 2021)
      Background Muscle wasting and unintentional weight loss (cachexia) have been associated with worse outcomes in heart failure (HF), but timely identification of these adverse phenomena is difficult. Spot urinary creatinine ...