Browsing Bergen Open Research Archive by Author "Zeltz, Cedric"
Now showing items 1-9 of 9
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Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
Zeltz, Cedric; Primac, Irina; Murugan Erusappan, Pugazendhi; Alam, Jahedul; Noel, Agnes; Gullberg, Donald (Peer reviewed; Journal article, 2019)The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle ... -
Collagen Assembly at the Cell Surface: Dogmas Revisited
Musiime, Moses; Chang, Joan; Hansen, Uwe; Kadler, Karl E.; Zeltz, Cedric; Gullberg, Elon Donald (Journal article; Peer reviewed, 2021)With the increased awareness about the importance of the composition, organization, and stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to understand the details of how cells ... -
Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation
Murugan Erusappan, Pugazendhi; Alam, Jahedul; Lu, Ning; Zeltz, Cedric; Gullberg, Donald (Peer reviewed; Journal article, 2019)Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both ... -
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?
Zeltz, Cedric; Navab, Roya; Heljasvaara, Ritva Leena; Gullberg, Marion Kusche; Lu, Ning; Tsao, Ming-Sound; Gullberg, Elon Donald (Journal article; Peer reviewed, 2022)There is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (CAFs) will ... -
Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs
Zeltz, Cedric; Orgel, Joseph; Gullberg, Donald (Peer reviewed; Journal article, 2014-08)Background: Despite detailed knowledge about the structure and signaling properties of individual collagen receptors, much remains to be learned about how these receptors participate in linking cells to fibrillar collagen ... -
Post-translational modifications of integrin ligands as pathogenic mechanisms in disease
Zeltz, Cedric; Gullberg, Donald (Peer reviewed; Journal article, 2014-11)Protein post-translational modifications like glycation, carbamylation and citrullination increase the functional diversity of the proteome but in disease situations might do more harm than good. Post-translational ... -
Reduced Granulation Tissue and Wound Strength in the Absence of α11β1 Integrin
Schulz, Jan-Niklas; Zeltz, Cedric; Sørensen, Ida Wiig; Barczyk, Malgorzata; Carracedo, Sergio; Hallinger, Ralf; Niehoff, Anja; Eckes, Beate; Gullberg, Donald (Peer reviewed; Journal article, 2015-12-08)Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin in fibroblast-mediated wound contraction, suggesting the involvement of another collagen receptor in this process. Our previous ... -
Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype
Bayer, Monika Lucia; Schjerling, Peter; Herchenhan, Andreas; Zeltz, Cedric; Heinemeier, Katja Maria; Christensen, Lise; Krogsgaard, Michael; Gullberg, Donald; Kjær, Michael (Peer reviewed; Journal article, 2014-01-21)Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion and collagen synthesis, but whether unloading removes these responses is unclear. We investigated ... -
α11β1 integrin is induced in a subset of cancer- associated fibroblasts in desmoplastic tumor stroma and mediates in vitro cell migration
Zeltz, Cedric; Alam, Jahedul; Liu, Hengshuo; Erusappan, Pugazendhi M; Hoschuetzky, Heinz; Molven, Anders; Parajuli, Himalaya; Cukierman, Edna; Costea, Daniela Elena; Lu, Ning; Gullberg, Donald (Peer reviewed; Journal article, 2019-06-01)Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further ...