Blar i Bergen Open Research Archive på forfatter "Zhou, Fan"

Viser treff 1-20 av 25

    • Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study 

      Kuwelker, Kanika; Zhou, Fan; Blomberg, Bjørn; Jalloh, Sarah Larteley Lartey; Brokstad, Karl Albert; Trieu, Mai Chi; Bansal, Amit; Madsen, Anders; Krammer, Florian; Mohn, Kristin Greve-Isdahl; Tøndel, Camilla; Linchausen, Dagrunn Waag; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2021)
      Background Households studies reflect the natural spread of SARS-CoV-2 in immunologically naive populations with limited preventive measures to control transmission. We hypothesise that seropositivity provides more ...

    • Augmented CD4+ T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years 

      Trieu, Mai Chi; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Sridhar, Saranya; Mjaaland, Siri; Cox, Rebecca Jane (Peer reviewed; Journal article, 2018-08-14)
      Annual seasonal influenza vaccination is recommended for high-risk populations and often occupational groups such as healthcare workers (HCWs). Repeated annual vaccination has been reported to either have no impact or ...

    • Boosting of cross-reactive and protection-associated T cells in children after live attenuated influenza vaccination 

      Mohn, Kristin Greve-Isdahl; Zhou, Fan; Brokstad, Karl Albert; Sridhar, Saranya; Cox, Rebecca Jane (Peer reviewed; Journal article, 2017-05)
      Background. Live attenuated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity, which may provide protection against newly emerging strains. This study shows proof of concept ...

    • A DNA vaccine that targets hemagglutinin to antigen-presenting cells protects mice against H7 influenza 

      Andersen, Tor Kristian; Zhou, Fan; Cox, Rebecca Jane; Bogen, Bjarne; Grødeland, Gunnveig (Peer reviewed; Journal article, 2017-12)
      Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently, no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability ...

    • Durable immune responses after BNT162b2 vaccination in home-dwelling old adults 

      Hansen, Lena; Brokstad, Karl Albert; Bansal, Amit; Zhou, Fan; Bredholt, Geir; Onyango, Therese Bredholt; Sandnes, Helene Heitmann; Elyanow, Rebecca; Madsen, Anders; Trieu, Mai Chi; Sævik, Marianne; Søyland, Hanne; Olofsson, Jan Stefan; Vahokoski, Juha; Ertesvåg, Nina Urke; Fjelltveit, Elisabeth Berg; Shafiani, Shahin; Tøndel, Camilla; Chapman, Heidi; Kaplan, Ian; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ...

    • Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients 

      Mohn, Kristin Greve-Isdahl; Bredholt, Geir; Zhou, Fan; Madsen, Anders Aasgaard; Onyango, Therese Bredholt; Fjelltveit, Elisabeth Berg; Jalloh, Sarah Larteley Lartey; Brokstad, Karl Albert; Cantoni, Diego; Mayora-Neto, Martin; Temperton, Nigel; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)
      Background Neutralizing antibodies are important for protection against the pandemic SARS-CoV-2 virus, and long-term memory responses determine the risk of re-infection or boosting after vaccination. T-cellular responses ...

    • Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection 

      Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan; Gullaksen, Stein-Erik; Skavland, Jørn; Chauhan, Sudhir Kumar; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2023)
      Enterotoxigenic Escherichia coli (ETEC) is an important cause of children's and travelers’ diarrhea, with no licensed vaccine. This study aimed to explore the role of cellular immunity in protection against human ETEC ...

    • The evolution of humoral immune responses to past and novel influenza virus strains gives evidence for antigenic seniority 

      Sicca, Federica; Sakorafa, Eleni; de Jonge, Anouk; de Vries-Idema, Jacqueline; Zhou, Fan; Cox, Rebecca Jane; Huckriede, Anke (Journal article; Peer reviewed, 2022)
      The high genetic and antigenic variability of influenza virus and the repeated exposures of individuals to the virus over time account for the human immune responses toward this pathogen to continuously evolve during the ...

    • Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014) 

      Amdam, Håkon; Madsen, Anders; Zhou, Fan; Bansal, Amit; Trieu, Mai Chi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Background: In 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique ...

    • Haemagglutination inhibition and virus microneutralisation serology assays: use of harmonised protocols and biological standards in seasonal influenza serology testing and their impact on inter-laboratory variation and assay correlation: A FLUCOP collaborative study 

      Waldock, Joanna; Remarque, Edmond J.; Zheng, Lingyi; Ho, Sammy; Hoschler, Katja; Neumann, Britta; Sediri-Schön, Hanna; Trombetta, Claudia M.; Montomoli, Emanuele; Marchi, Serena; Lapini, Giulia; Zhou, Fan; Jalloh, Sarah Larteley Lartey; Cox, Rebecca Jane; Facchini, Marzia; Castrucci, Maria Rita; Friel, Damien; Ollinger, Thierry; Caillet, Catherine; Music, Nedzad; Palladino, Giuseppe; Engelhardt, Othmar G. (Journal article; Peer reviewed, 2023)
      Introduction: The haemagglutination inhibition assay (HAI) and the virus microneutralisation assay (MN) are long-established methods for quantifying antibodies against influenza viruses. Despite their widespread use, both ...

    • Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus 

      Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana; Lotsberg, Maria Lie; Ramnefjell, Maria; Hoareau, Laurence; Røsland, Gro Vatne; Lu, Ning; Aanerud, Marianne; Gärtner, Fabian; Salminen, Pirjo-Riitta; Bentsen, Mariann; Halvorsen, Thomas; Ræder, Helge; Akslen, Lars Andreas; Langeland, Nina; Brokstad, Rebecca Jane Cox; Maury, Wendy; Stuhr, Linda Elin Birkhaug; Lorens, James; Engelsen, Agnete Svendsen Tenfjord (Journal article; Peer reviewed, 2022)
      The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts to understand the pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ...

    • Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction 

      Jalloh, Sarah Larteley Lartey; Zhou, Fan; Brokstad, Karl Albert; Mohn, Kristin Greve-Isdahl; Slettevoll, Steffen Aleksander; Pathirana, Rishi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)
      Background: Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and ...

    • Long COVID in a prospective cohort of home-isolated patients 

      Blomberg, Bjørn; Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Zhou, Fan; Linchausen, Dagrunn Waag; Hansen, Bernt-Are; Jalloh, Sarah Larteley Lartey; Onyango, Therese Bredholt; Kuwelker, Kanika; Sævik, Marianne; Bartsch, Hauke; Tøndel, Camilla; Kittang, Bård Reiakvam; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2021)
      Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a ...

    • Matrix M Adjuvanted H5N1 Vaccine Elicits Broadly Neutralizing Antibodies and Neuraminidase Inhibiting Antibodies in Humans That Correlate With In Vivo Protection 

      Zhou, Fan; Hansen, Lena; Pedersen, Gabriel Kristian; Grødeland, Gunnveig; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      The highly pathogenic avian influenza H5N1 viruses constantly evolve and give rise to novel variants that have caused widespread zoonotic outbreaks and sporadic human infections. Therefore, vaccines capable of eliciting ...

    • A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease 

      Zimmermann, Julie; Schmidt, Signe Tandrup; Trebbien, Ramona; Cox, Rebecca Jane; Zhou, Fan; Follmann, Frank; Pedersen, Gabriel Kristian; Christensen, Dennis (Journal article; Peer reviewed, 2022-02-06)
      The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ...

    • Persistent Fever and Positive PCR 90 Days Post-SARS-CoV-2 Infection in a Rituximab-Treated Patient: A Case of Late Antiviral Treatment 

      Ertesvåg, Nina Urke; Sakkestad, Sunniva Todnem; Zhou, Fan; Hoff, Ingrid; Kristiansen, Trygve; Jonassen, Trygve Müller; Follesø, Elisabeth; Brokstad, Karl Albert; Dyrhovden, Ruben; Mohn, Kristin Greve-Isdahl (Journal article; Peer reviewed, 2022)
      Background: Persistent fever after SARS-CoV-2 infection in rituximab-treated patients has been reported. Due to reduced sensitivity in conventional sampling methods and unspecific symptoms in these patients, distinguishing ...

    • A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern 

      Ertesvåg, Nina Urke; Xiao, Julie; Zhou, Fan; Ljostveit, Sonja; Sandnes, Helene Heitmann; Lartey, Sarah; Sævik, Marianne; Hansen, Lena; Madsen, Anders; Mohn, Kristin Greve-Isdahl; Fjelltveit, Elisabeth Berg; Olofsson, Jan Stefan; Tan, Tiong Kit; Rijal, Pramilia; Schimanski, Lisa; Øyen, Siri; Brokstad, Karl Albert; Dunachie, Susanna; Jämsén, Anni; James, William S.; Harding, Adam C.; Harvala, Heli; Nguyen, Dung; Roberts, David; Patel, Monika; Gopal, Robin; Zambon, Maria; Wei, Leiyan; Gilbert-Jaramillo, Javier; Knight, Michael L.; Vaughan-Jackson, Alun; Dupont, Maeva; Lamikanra, Abigail A.; Klennerman, Paul; Townsend, Alain; Tøndel, Camilla; Kuwelker, Kanika; Blomberg, Bjørn; Bredholt, Geir; Onyango, Therese Bredholt; Vahokoski, Juha; Bansal, Amit; Trieu, Mai Chi; Amdam, Håkon; Akselsen, Per Espen; Skorge, Trude Duelien; Okkenhaug, Liv Heiberg; Linchausen, Dagrun Waag; Langeland, Nina; Cox Brokstad, Rebecca Jane (Journal article; Peer reviewed, 2022)
      Background: Evaluation of susceptibility to emerging SARS-CoV-2 variants of concern (VOC) requires rapid screening tests for neutralising antibodies which provide protection. Methods: Firstly, we developed a receptor-binding ...

    • Repeated Influenza Vaccination Boosts and Maintains H1N1pdm09 Neuraminidase Antibody Titers 

      Hansen, Lena; Zhou, Fan; Amdam, Håkon; Trieu, Mai Chi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Antibodies to influenza surface protein neuraminidase (NA) have been found to reduce disease severity and may be an independent correlate of protection. Despite this, current influenza vaccines have no regulatory requirements ...

    • SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients 

      Onyango, Therese Bredholt; Zhou, Fan; Bredholt, Geir; Brokstad, Karl Albert; Jalloh, Sarah Larteley Lartey; Mohn, Kristin Greve-Isdahl; Özgümüs, Türküler; Kittang, Bård Reiakvam; Linchausen, Dagrun Waag; Shafiani, Shahin; Elyanow, Rebecca; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Obesity is a known risk factor for severe respiratory tract infections. In this prospective study, we assessed the impact of being obese or overweight on longitudinal SARS-CoV-2 humoral and cellular responses up to 18 ...

    • SARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study 

      Trieu, Mai Chi; Bansal, Amit; Madsen, Anders; Zhou, Fan; Sævik, Marianne; Vahokoski, Juha; Brokstad, Karl Albert; Krammer, Florian; Tøndel, Camilla; Mohn, Kristin Greve-Isdahl; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity ...