Blar i Bergen Open Research Archive på forfatter "de Simone, Giovanni"
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Association of myocardial energetic efficiency with circumferential and longitudinal left ventricular myocardial function in subjects with increased body mass index (The FATCOR study)
Mancusi, Costantino; Midtbø, Helga Bergljot; De Luca, Nicola; Halland, Hilde; de Simone, Giovanni; Gerdts, Eva (Journal article; Peer reviewed, 2021)Lower myocardial mechanic-energetic efficiency (MEEi), expressed as stroke volume/heart rate ratio (SV/HR) in mL/s/g of the left ventricular (LV) mass, is associated with the incidence of heart failure in subjects with ... -
Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation
Ludvigsen, Stian; Mancusi, Costantino; Kildal, Simon; de Simone, Giovanni; Gerdts, Eva; Ytrehus, Kirsti (Peer reviewed; Journal article, 2018-02-08)Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt‐dependent hypertension. Dahl salt‐sensitive rats, age 12 ... -
Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
Ytrehus, Kirsti; Gerdts, Eva; Mancusi, Costatino; de Simone, Giovanni; Ludvigsen, Stian (Journal article; Peer reviewed, 2021)Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to ... -
Hypertension in women: Should there be a sex-specific threshold?
Gerdts, Eva; de Simone, Giovanni (Journal article; Peer reviewed, 2021)Conventionally, hypertension is defined by the same blood pressure (BP) threshold (systolic BP ≥140 and/or diastolic BP ≥90 mmHg) in both women and men. Several studies have documented that women with hypertension are more ... -
Sex differences in arterial hypertension
Gerdts, Eva; Sudano, Isabella; Brouwers, Sofie; Borghi, Claudio; Bruno, RM; Ceconi, Claudio; Cornelissen, Veronique; Dievart, Francois; Ferrini, Marc; Kahan, Thomas; Løchen, Maja-Lisa; Maas, Angela H.E.M.; Mahfoud, Felix; Mihailidou, Anastasia Susie; Moholdt, Trine; Parati, Gianfranco; de Simone, Giovanni (Journal article; Peer reviewed, 2022)There is strong evidence that sex chromosomes and sex hormones influence blood pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities differentially in females and males with essential ...