• AXL is a driver of stemness in normal mammary gland and breast cancer 

      Engelsen, Agnete; Wnuk-Lipinska, Katarzyna; Bougnaud, Sébastien; Vatter, Fanny A. Pelissier; Tiron, Crina Elena; Villadsen, René; Miyano, Masaru; Lotsberg, Maria Lie; Madeleine, Noëlly; Panahandeh, Pouda; Dhakal, Sushil; Tan, Tuan Zea; Peters, Stacey D'Mello; Grøndal, Sturla Magnus; Aziz, Sura Mohammed; Nord, Silje; Herfindal, Lars; Stampfer, Martha R.; Sørlie, Therese; Brekken, Rolf A; Straume, Oddbjørn; Halberg, Nils; Gausdal, Gro; Thiery, Jean Paul; Akslen, Lars A.; Petersen, Ole W.; LaBarge, Mark A.; Lorens, James (Journal article; Peer reviewed, 2020)
      The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ...
    • Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation 

      Miyano, Masaru; Sayaman, Rosalyn W.; Shalabi, Sundus F.; Senapati, Parijat; Lopez, Jennifer C.; Angarola, Brittany Lynn; Hinz, Stefan; Zirbes, Arrianna; Anczukow, Olga; Yee, Lisa D.; Sedrak, Mina S.; Stampfer, Martha R.; Seewaldt, Victoria; LaBarge, Mark A. (Journal article; Peer reviewed, 2021)
      A robust breast cancer prevention strategy requires risk assessment biomarkers for early detection. We show that expression of ELF5, a transcription factor critical for normal mammary development, is downregulated in mammary ...
    • Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression 

      Zirbes, Arrianna; Joseph, Jesuchristopher; Lopez, Jennifer C.; Sayaman, Rosalyn W.; Basam, Mudaser; Seewaldt, Victoria; LaBarge, Mark A. (Journal article; Peer reviewed, 2021)
      A majority of breast cancers (BC) are age-related and we seek to determine what cellular and molecular changes occur in breast tissue with age that make women more susceptible to cancer initiation. Immune-epithelial cell ...
    • Microsphere cytometry to interrogate microenvironment-dependent cell signaling 

      Ertsås, Henriette Christie; Nolan, Garry P.; LaBarge, Mark A.; Lorens, James (Journal article; Peer reviewed, 2017)
      Microenvironmental cues comprising surface-mediated and soluble factors control cellular signaling mechanisms underlying normal cellular responses that define homeostatic and diseased cell states. In order to measure cell ...