Blar i Registrations from Cristin på forfatter "Ulvestad, Elling"
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The changing spectrum of microbial aetiology of respiratory tract infections in hospitalized patients before and during the COVID-19 pandemic
Serigstad, Sondre; Markussen, Dagfinn Lunde; Ritz, Christian; Ebbesen, Marit Helen; Knoop, Siri Tandberg; Kommedal, Øyvind; Heggelund, Lars; Ulvestad, Elling; Bjørneklett, Rune Oskar; Grewal, Harleen (Journal article; Peer reviewed, 2022-09-30)Background: The COVID-19 pandemic was met with strict containment measures. We hypothesized that societal infection control measures would impact the number of hospital admissions for respiratory tract infections, as well ... -
Comparison of rapid molecular testing methods for detecting respiratory viruses in emergency care: a prospective study
Markussen, Dagfinn Lunde; Grewal, Harleen; Knoop, Siri Tandberg; Serigstad, Sondre; Kommedal, Øyvind; Ebbesen, Marit Helen; Ulvestad, Elling; Bjørneklett, Rune Oskar (Journal article; Peer reviewed, 2022)Background Respiratory tract infections (RTIs) caused by contagious viruses are common among patients presenting to the emergency department (ED). Early detection of these viruses can help prevent nosocomial transmissio ... -
Diagnostic utility of oropharyngeal swabs as an alternative to lower respiratory tract samples for PCR-based syndromic testing in patients with community-acquired pneumonia
Serigstad, Sondre; Knoop, Siri Tandberg; Markussen, Dagfinn Lunde; Ulvestad, Elling; Bjørneklett, Rune Oskar; Ebbesen, Marit Helen; Kommedal, Øyvind; Grewal, Harleen (Journal article; Peer reviewed, 2023)Syndromic PCR-based analysis of lower respiratory tract (LRT) samples in patients with community-acquired pneumonia (CAP) improves the bacterial yield and time-to-results compared to culture-based methods. However, obtaining ... -
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
Siljan, William Ward; Sivakumaran, Dhanasekaran; Ritz, Christian; Jenum, Synne; Ottenhoff, Tom HM; Ulvestad, Elling; Holter, Jan Cato; Heggelund, Lars; Grewal, Harleen (Journal article; Peer reviewed, 2022)Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ... -
Humoral response to Epstein-Barr virus in patients with multiple sclerosis treated with B cell depletion therapy
Rød, Brit Ellen; Wergeland, Stig; Bjørnevik, Kjetil Lauvland; Holmøy, Trygve; Ulvestad, Elling; Njølstad, Gro; Myhr, Kjell-Morten; Torkildsen, Øivind (Journal article; Peer reviewed, 2023)Background B cell depletion therapy is highly effective in relapsing-remitting multiple sclerosis (RRMS). However, the precise underlying mechanisms of action for its biological effects in MS have still not been clarified. ... -
Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR)
Serigstad, Sondre; Ritz, Christian; Faurholt-Jepsen, Daniel; Markussen, Dagfinn Lunde; Ebbesen, Marit Helen; Kommedal, Øyvind; Bjørneklett, Rune Oskar; Heggelund, Lars; Clark, Tristan W.; van Werkhoven, Cornelis H.; Knoop, Siri Tandberg; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2022)Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ... -
Investigating the human jejunal microbiota
Villmones, Heidi Cecilie; Svanevik, Marius; Ulvestad, Elling; Stenstad, Tore; Anthonisen, Inger Lill; Nygaard, Randi Monsen; Dyrhovden, Ruben; Kommedal, Øyvind (Journal article; Peer reviewed, 2022)Descriptions of the small intestinal microbiota are deficient and conflicting. We aimed to get a reliable description of the jejunal bacterial microbiota by investigating samples from two separate jejunal segments collected ... -
Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers
Dyrhovden, Ruben; Rippin, Martin; Øvrebø, Kjell Kåre; Nygaard, Randi Monsen; Ulvestad, Elling; Kommedal, Øyvind (Journal article; Peer reviewed, 2021)In this article, we investigate patterns of microbial DNA contamination in targeted 16S rRNA amplicon sequencing (16S deep sequencing) and demonstrate how this can be used to filter background bacterial DNA in diagnostic ... -
Rapid syndromic PCR testing in patients with respiratory tract infections reduces time to results and improves microbial yield
Serigstad, Sondre; Grewal, Harleen; Ebbesen, Marit Helen; Kommedal, Øyvind; Heggelund, Lars; van Werkhoven, Werkhoven; Faurholt-Jepsen, Daniel; Clark, T.W.; Ritz, Christian; Ulvestad, Elling; Bjørneklett, Rune Oskar; Knoop, Siri Tandberg; Ravn, P.; Markussen, Dagfinn Lunde (Journal article; Peer reviewed, 2022)Lack of rapid and comprehensive microbiological diagnosis in patients with community acquired pneumonia (CAP) hampers appropriate antimicrobial therapy. This study evaluates the real-world performance of the BioFire FilmArray ... -
Seroprevalence of SARS-CoV-2 antibodies in a prospective cohort of patients admitted to an acute psychiatric ward in Norway during the initial months of the COVID-19 pandemic
Kroken, Rune Andreas; Stabell, Lena Antonsen; Grewal, Harleen; Ulvestad, Elling; Landsnes, Andreas Johan; Johnsen, Erik (Journal article; Peer reviewed, 2023)Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) spread around the world during the first part of 2020. The purpose of the study was to assess ... -
Species Level Description of the Human Ileal Bacterial Microbiota
Villmones, Heidi Cecilie; Haug, Erik Skaaheim; Ulvestad, Elling; Grude, Nils; Stenstad, Tore; Halland, Adrian; Kommedal, Øyvind (Journal article; Peer reviewed, 2018)The small bowel is responsible for most of the body’s nutritional uptake and for the development of intestinal and systemic tolerance towards microbes. Nevertheless, the human small bowel microbiota has remained poorly ...