• Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging 

      Dugué, Pierre-Antoine; Hodge, Allison M.; Ulvik, Arve; Ueland, Per Magne; Midttun, Øyvind; Rinaldi, Sabina; MacInnis, Robert J.; Li, Sherly X.; Meyer, Klaus; Navionis, Anne-Sophie; Flicker, Leon; Severi, Gianluca; English, Dallas R.; Vineis, Paolo; Tell, Grethe S.; Southey, Melissa C.; Milne, Roger L.; Giles, Graham G. (Journal article; Peer reviewed, 2021)
      Background Inflammation is a key feature of aging. We aimed to (i) investigate the association of 34 blood markers potentially involved in inflammatory processes with age and mortality and (ii) develop a signature of ...
    • A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Clasen, Joanna L; Heath, Alicia K.; Van Puyvelde, Heleen; Huybrechts, Inge; Park, Jin Young; Ferrari, Pietro; Johansson, Mattias; Scelo, Ghislaine; Ulvik, Arve; Midttun, Øivind; Ueland, Per Magne; Dahm, Christina C; Halkjær, Jytte; Olsen, Anja; Johnson, Theron; Katzke, Verena; Schulze, Matthias B; Masala, Giovanna; Segrado, Francesco; De Magistris, Maria Santucci; Sacerdote, Carlotta; Ocké, Marga C; Luján-Barroso, Leila; Ching-López, Ana; Huerta, José María; Ardanaz, Eva; Amiano, Pilar; Ericson, Ulrika; Manjer, Jonas; Gylling, Björn; Johansson, Ingegerd; Schmidt, Julie; Weiderpass, Elisabete; Riboli, Elio; Cross, Amanda J; Muller, David C (Journal article; Peer reviewed, 2021)
      Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. ...
    • Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: A randomised trial 

      Bratlie, Marianne; Hagen, Ingrid Valheim; Helland, Anita; Midttun, Øivind; Ulvik, Arve; Rosenlund, Grethe; Sveier, Harald; Mellgren, Gunnar; Ueland, Per Magne; Gudbrandsen, Oddrun Anita (Journal article; Peer reviewed, 2020)
      Low serum concentrations of several vitamins have been linked to increased risk of diseases including insulin resistance and type 2 diabetes (T2D). Fish is a good source of several vitamins, and the prevalence of T2D is ...
    • Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study 

      Alme, Katinka Nordheim; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Ulvik, Arve; Knapskog, Anne-Brita (Journal article; Peer reviewed, 2021)
      Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ...
    • Microheterogeneity and preanalytical stability of protein biomarkers of inflammation and renal function 

      Gao, Jie; Ulvik, Arve; McCann, Adrian; Ueland, Per Magne; Meyer, Klaus (Journal article; Peer reviewed, 2021)
      Protein biomarker microheterogeneity has attracted increasing attention in epidemiological and clinical research studies. Knowledge concerning the preanalytical stability of proteins is paramount to assess the biological ...
    • Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of infammation measured three months after ischemic stroke 

      Alme, Katinka Nordheim; Ulvik, Arve; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Knapskog, Anne Brita (Journal article; Peer reviewed, 2021)
      Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation ...
    • The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase 

      Aubi Catevilla, Oscar; Prestegård, Karina Skjervheim; K C, Kunwar Jung; Shi, Tie-Jun; Ying, Ming; Grindheim, Ann Kari; Scherer, Tanja; Ulvik, Arve; McCann, Adrian; Spriet, Endy; Thöny, Beat; Martinez, Aurora (Journal article; Peer reviewed, 2021)
      Phenylketonuria (PKU) is caused by autosomal recessive variants in phenylalanine hydroxylase (PAH), leading to systemic accumulation of L-phenylalanine (L-Phe) that may reach neurotoxic levels. A homozygous Pah-R261Q mouse, ...
    • Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients 

      Ulvik, Arve; Midttun, Øivind; McCann, Adrian; Meyer, Klaus; Tell, Grethe S.; Nygård, Ottar; Ueland, Per Magne (Journal article; Peer reviewed, 2020)
      Background Vitamin B-6 status is routinely measured as pyridoxal 5′-phosphate (PLP) in plasma. Low concentrations of PLP are associated with rheumatic, cardiovascular, and neoplastic diseases. We have previously shown ...
    • Vitamin B6 catabolism and lung cancer risk: Results from the Lung Cancer Cohort Consortium (LC3) 

      Zuo, Hui; Ueland, Per Magne; Midttun, Øivind; Tell, Grethe S.; Fanidi, Anouar; Zheng, Wei; Shu, Xiao-Ou; Xiang, Yong-Bing; Wu, Jie; Prentice, Ross L.; Pettinger, Mary; Thomson, Cynthia A.; Giles, Graham G.; Hodge, Allison M.; Cai, Qiuyin; Blot, William J.; Johansson, Mikael B.; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Ziegler, Regina G.; Freedman, Neal David; Caporaso, Neil E.; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Buring, Julie E.; Lee, I-Min; Gaziano, John Michael; Severi, Gianluca; Zhang, Xuehong; Stampfer, Meir Jonathan; Han, Jiali; Zeleniuch-Jacquotte, Anne; Marchand, Loïc Le; Yuan, Jian-Min; Wang, Renwei; Koh, Woon-Puay; Gao, Yutang; Ericson, Ulrika C.; Visvanathan, Kala; Jones, Michael R.; Relton, Caroline Laura; Brennan, Paul J.; Johansson, Mattias; Ulvik, Arve (Journal article; Peer reviewed, 2019-03)
      Background Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with ...