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dc.contributor.authorHansen, Anita Lill
dc.contributor.authorAmbroziak, Gina
dc.contributor.authorThornton, David
dc.contributor.authorMundt, James C.
dc.contributor.authorKahn, Rachel E.
dc.contributor.authorDahl, Lisbeth
dc.contributor.authorWaage, Leif
dc.contributor.authorKattenbraker, Daniel
dc.contributor.authorAraujo, Pedro
dc.contributor.authorMurison, Robert
dc.contributor.authorRypdal, Knut
dc.contributor.authorGrung, Bjørn
dc.date.accessioned2021-02-12T10:57:24Z
dc.date.available2021-02-12T10:57:24Z
dc.date.created2020-11-08T13:02:40Z
dc.date.issued2020
dc.PublishedNutrients. 2020, 12 (11), 1-21.
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/11250/2727699
dc.description.abstractVitamin D status may be important for stress resilience. This study investigated the effects of vitamin D supplements during winter on biological markers of stress resilience such as psychophysiological activity, serotonin, and cortisol in a placebo-controlled, randomized clinical trial. Eighty-six participants were randomly assigned to the Intervention (vitamin D) or Control (placebo) groups. Before and after the intervention participants were exposed to an experimental stress procedure. Psychophysiological activity was measured during three main conditions: baseline, stress, and recovery. Fasting blood samples were taken in the morning and saliva samples were collected at seven different time points across 24 h. Prior to intervention both groups had normal/sufficient vitamin D levels. Both groups showed a normal pattern of psychophysiological responses to the experimental stress procedure (i.e., increased psychophysiological responses from resting baseline to stress-condition, and decreased psychophysiological responses from stress-condition to recovery; all p < 0.009). Post-intervention, the Intervention group showed increased vitamin D levels (p < 0.001) and normal psychophysiological responses to the experimental stress procedure (p < 0.001). Importantly, the Control group demonstrated a classic nadir in vitamin D status post-intervention (spring) (p < 0.001) and did not show normal psychophysiological responses. Thus, physiologically the Control group showed a sustained stress response. No significant effects of vitamin D were found on serotonin and cortisol.en_US
dc.language.isoengen_US
dc.publisherMDPI
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleVitamin D supplementation during winter: Effects on stress resilience in a randomized control trialen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 by the Authors.en_US
dc.source.articlenumber3258en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/nu12113258
dc.identifier.cristin1845908
dc.source.journalNutrientsen_US
dc.source.4012
dc.source.1411
dc.source.pagenumber1-21en_US
dc.identifier.citationNutrients 2020, 12(11), 3258en_US
dc.source.volume12en_US
dc.source.issue11en_US


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