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dc.contributor.authorGuttormsen, Yngve
dc.contributor.authorFairhurst, Magnus John Espeland
dc.contributor.authorPandey, Sunil Kumar
dc.contributor.authorIsaksson, Johan
dc.contributor.authorHaug, Bengt Erik
dc.contributor.authorBayer, Annette
dc.date.accessioned2021-02-12T14:19:15Z
dc.date.available2021-02-12T14:19:15Z
dc.date.created2020-10-18T14:24:14Z
dc.date.issued2020
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/11250/2727831
dc.description.abstractPhorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the trichlorinated phorbazole B using late stage electrophilic chlorination was developed. The synthesis relied on the use of an oxazole precursor, which was protected with an iodine in the reactive 4-position, followed by complete chlorination of all pyrrole positions. Attempts to prepare phorbazole A and C, which contain a 3,4-dichlorinated pyrrole, were unsuccessful as the desired chlorination pattern on the pyrrole could not be obtained. The identities of the dichlorinated intermediates and products were determined using NMR techniques including NOESY/ROESY, 1,1-ADEQUATE and high-resolution CLIP-HSQMBC.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleTotal Synthesis of Phorbazole Ben_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright © 2020 by the authors.en_US
dc.source.articlenumber4848en_US
cristin.ispublishedfalse
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/molecules25204848
dc.identifier.cristin1840370
dc.source.journalMoleculesen_US
dc.identifier.citationMolecules. 2020, 25 (20), 4848en_US
dc.source.volume25en_US
dc.source.issue20en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal