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dc.contributor.authorLugo, Alessandra
dc.contributor.authorEdvall, Niklas K.
dc.contributor.authorLazar, Andra
dc.contributor.authorMehraei, Golbarg
dc.contributor.authorLopez-Escamez, Jose Antonio
dc.contributor.authorBulla, Jan
dc.contributor.authorUhlen, Inger
dc.contributor.authorCanlon, Barbara
dc.contributor.authorGallus, Silvano
dc.contributor.authorCederroth, Christopher R
dc.date.accessioned2021-02-16T11:59:13Z
dc.date.available2021-02-16T11:59:13Z
dc.date.created2020-12-02T18:08:34Z
dc.date.issued2020-05
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2728369
dc.description.abstractThe heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n = 1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n = 660) or without (n = 1,879) headaches. In a multivariable logistic regression model, headache was significantly associated with any tinnitus (odds ratio, OR = 2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI ≥ 48; OR = 5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥ 58; OR = 4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics differed between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer differences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleRelationship between headaches and tinnitus in a Swedish studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright the Author(s)en_US
dc.source.articlenumber8494en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.1038/s41598-020-65395-1
dc.identifier.cristin1855518
dc.source.journalScientific Reportsen_US
dc.source.4010
dc.source.148494
dc.source.pagenumber1-12en_US
dc.source.volume10en_US


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