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dc.contributor.authorCederroth, Christopher R
dc.contributor.authorLugo, Alessandra
dc.contributor.authorEdvall, Niklas K.
dc.contributor.authorLazar, Andra
dc.contributor.authorLopez-Escamez, Jose Antonio
dc.contributor.authorBulla, Jan
dc.contributor.authorUhlen, Inger
dc.contributor.authorHoare, Darek J.
dc.contributor.authorBaguley, David M.
dc.contributor.authorCanlon, Barbara
dc.contributor.authorGallus, Silvano
dc.date.accessioned2021-02-16T12:09:33Z
dc.date.available2021-02-16T12:09:33Z
dc.date.created2020-12-02T18:04:34Z
dc.date.issued2020-07
dc.PublishedJournal of Clinical Medicine. 2020, 9 (2414), 1-13.
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/11250/2728373
dc.description.abstractMany individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of 3645 participants (1984 with tinnitus and 1661 without tinnitus) were enrolled via LifeGene, a study from the general Swedish population, aged 18–90 years, and provided information on socio-demographic characteristics, as well as presence of hyperacusis and its severity. Tinnitus presence and severity were self-reported or assessed using the Tinnitus Handicap Inventory (THI). Phenotypes of tinnitus with (n = 1388) or without (n = 1044) hyperacusis were also compared. Of 1661 participants without tinnitus, 1098 (66.1%) were women and 563 were men (33.9%), and the mean (SD) age was 45.1 (12.9). Of 1984 participants with tinnitus, 1034 (52.1%) were women and 950 (47.9%) were men, and the mean (SD) age was 47.7 (14.0) years. Hyperacusis was associated with any tinnitus [Odds ratio (OR) 3.51, 95% confidence interval (CI) 2.99–4.13], self-reported severe tinnitus (OR 7.43, 95% CI 5.06–10.9), and THI ≥ 58 (OR 12.1, 95% CI 7.06–20.6). The association with THI ≥ 58 was greater with increasing severity of hyperacusis, the ORs being 8.15 (95% CI 4.68–14.2) for moderate and 77.4 (95% CI 35.0–171.3) for severe hyperacusis. No difference between sexes was observed in the association between hyperacusis and tinnitus. The occurrence of hyperacusis in severe tinnitus is as high as 80%, showing a very tight relationship. Discriminating the pathophysiological mechanisms between the two conditions in cases of severe tinnitus will be challenging, and optimized study designs are necessary to better understand the mechanisms behind the strong relationship between hyperacusis and tinnitus.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAssociation between Hyperacusis and Tinnitusen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright by the authorsen_US
dc.source.articlenumber2412en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://dx.doi.org/10.3390/jcm9082412
dc.identifier.cristin1855514
dc.source.journalJournal of Clinical Medicineen_US
dc.source.409
dc.source.142414
dc.source.pagenumber1-13en_US
dc.source.volume9en_US
dc.source.issue8en_US


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