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dc.contributor.authorOusdal, Olga Therese
dc.contributor.authorMilde, Anne Marita
dc.contributor.authorHafstad, Gertrud Sofie
dc.contributor.authorHodneland, Erlend
dc.contributor.authorDyb, Grete
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorMelinder, Annika Maria D
dc.contributor.authorEndestad, Tor
dc.contributor.authorHugdahl, Kenneth
dc.date.accessioned2021-02-16T15:33:45Z
dc.date.available2021-02-16T15:33:45Z
dc.date.created2020-08-26T13:15:17Z
dc.date.issued2020
dc.identifier.issn2158-3188
dc.identifier.urihttps://hdl.handle.net/11250/2728509
dc.description.abstractThe amygdala is a core component in neurobiological models of stress and stress-related pathologies, including post-traumatic stress disorder (PTSD). While numerous studies have reported increased amygdala activity following traumatic stress exposure and in PTSD, the findings regarding amygdala volume have been mixed. One reason for these mixed findings may be that the amygdala has been considered as a homogenous entity, while it in fact consists of several nuclei with unique cellular and connectivity profiles. Here, we investigated amygdala nuclei volumes of the basolateral and the centrocorticomedial complex in relation to PTSD symptom severity in 47 young survivors from the 2011 Norwegian terror attack 24–36 months post-trauma. PTSD symptoms were assessed 4–5, 14–15 and 24–36 months following the trauma. We found that increased PTSD symptom severity 24–36 months post-trauma was associated with volumetric reductions of all basolateral as well as the central and the medial nuclei. However, only the lateral nucleus was associated with longitudinal symptom development, and mediated the association between 4–5 months and 24–36 months post-trauma symptoms. The results suggest that the amygdala nuclei may be differentially associated with cross-sectional and longitudinal measures of PTSD symptom severity. As such, investigations of amygdala total volume may not provide an adequate index of the association between amygdala and stress-related mental illness.en_US
dc.language.isoengen_US
dc.publisherBMCen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe association of PTSD symptom severity with amygdala nuclei volumes in traumatized youthsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 The Author(s).en_US
dc.source.articlenumber288en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doihttps://doi.org/10.1038/s41398-020-00974-4
dc.identifier.cristin1825260
dc.source.journalTranslational Psychiatryen_US
dc.source.4010
dc.source.14288
dc.identifier.citationTranslational Psychiatry. 2020, 10, 288en_US
dc.source.volume10en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal