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dc.contributor.authorAarstad, Helene Hersvik
dc.contributor.authorGudbrandsdottir, Gigja
dc.contributor.authorHjelle, Karin
dc.contributor.authorBostad, Leif
dc.contributor.authorBruserud, Øystein
dc.contributor.authorTvedt, Tor Henrik Anderson
dc.contributor.authorBeisland, Christian
dc.date.accessioned2021-02-18T09:04:53Z
dc.date.available2021-02-18T09:04:53Z
dc.date.created2020-08-26T11:55:14Z
dc.date.issued2020
dc.PublishedCancers. 2020, 12:1961 (7), 1-18.
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/11250/2728841
dc.description.abstractHigh serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. This overall profile of the response depends on the inducing event and can also differ between patients. We investigated an extended acute phase cytokine profile for 97 renal cancer patients. Initial studies showed that the serum CRP levels had an expected prognostic association together with tumor size, stage, nuclear grading, and Leibovich score. Interleukin (IL)6 family cytokines, IL1 subfamily mediators, and tumor necrosis factor (TNF)α can all be drivers of the acute phase response. Initial studies suggested that serum IL33Rα (the soluble IL33 receptor α chain) levels were also associated with prognosis, although the impact of IL33Rα is dependent on the overall cytokine profile, including seven IL6 family members (IL6, IL6Rα, gp130, IL27, IL31, CNTF, and OSM), two IL1 subfamily members (IL1RA and IL33Rα), and TNFα. We identified a patient subset characterized by particularly high levels of IL6, IL33Rα, and TNFα alongside an adverse prognosis. Thus, the acute phase cytokine reaction differs between renal cancer patients, and differences in the acute phase cytokine profile are associated with prognosis.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profileen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 by the authors.en_US
dc.source.articlenumber1961en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/cancers12071961
dc.identifier.cristin1825239
dc.source.journalCancersen_US
dc.source.4012:1961
dc.source.147
dc.identifier.citationCancers. 2020, 12 (7), 1961.en_US
dc.source.volume12en_US
dc.source.issue7en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal