dc.contributor.author | Kompus, Kristiina | |
dc.contributor.author | Volehaugen, Vegard | |
dc.contributor.author | Craven, Alexander R. | |
dc.contributor.author | Specht, Karsten | |
dc.date.accessioned | 2021-03-01T14:01:51Z | |
dc.date.available | 2021-03-01T14:01:51Z | |
dc.date.created | 2020-10-02T14:17:50Z | |
dc.date.issued | 2020 | |
dc.Published | Scientific Reports. 2020, 10:115059 1-10. | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/11250/2730983 | |
dc.description.abstract | In a stable environment the brain can minimize processing required for sensory input by forming a predictive model of the surrounding world and suppressing neural response to predicted stimuli. Unpredicted stimuli lead to a prediction error signal propagation through the perceptual network, and resulting adjustment to the predictive model. The inter-regional plasticity which enables the model-building and model-adjustment is hypothesized to be mediated via glutamatergic receptors. While pharmacological challenge studies with glutamate receptor ligands have demonstrated impact on prediction-error indices, it is not clear how inter-individual differences in the glutamate system affect the prediction-error processing in non-medicated state. In the present study we examined 20 healthy young subjects with resting-state proton MRS spectroscopy to characterize glutamate + glutamine (rs-Glx) levels in their Heschl’s gyrus (HG), and related this to HG functional connectivity during a roving auditory oddball protocol. No rs-Glx effects were found within the frontotemporal prediction-error network. Larger rs-Glx signal was related to stronger connectivity between HG and bilateral inferior parietal lobule during unpredictable auditory stimulation. We also found effects of rs-Glx on the coherence of default mode network and frontoparietal network during unpredictable auditory stimulation. Our results demonstrate the importance of Glx in modulating long-range connections and wider networks in the brain during perceptual inference. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2020 The Author(s). | en_US |
dc.source.articlenumber | 15059 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1038/s41598-020-72044-0 | |
dc.identifier.cristin | 1836621 | |
dc.source.journal | Scientific Reports | en_US |
dc.source.40 | 10:115059 | |
dc.identifier.citation | Scientific Reports. 2020, 10, 15059 | en_US |
dc.source.volume | 10 | en_US |