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dc.contributor.authorAarstad, Helene Hersvik
dc.contributor.authorMoe, Svein Erik Emblem
dc.contributor.authorBruserud, Øystein
dc.contributor.authorLybak, Stein
dc.contributor.authorAarstad, Hans Jørgen
dc.contributor.authorTvedt, Tor Henrik Anderson
dc.date.accessioned2021-05-03T12:28:23Z
dc.date.available2021-05-03T12:28:23Z
dc.date.created2020-11-08T14:14:12Z
dc.date.issued2020
dc.PublishedBiomedicines. 2020, 8:418 (10), 1-26.
dc.identifier.issn2227-9059
dc.identifier.urihttps://hdl.handle.net/11250/2753287
dc.description.abstractC-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction inducers. In the present study, we compared the pretreatment acute phase cytokine profile for 144 patients with potentially curative HNSCC. We investigated the systemic levels of interleukin (IL)6 family mediators (glycoprotein (gp130), IL6 receptor (R)α, IL6, IL27, IL31, oncostatin M (OSM), ciliary neurotrophic factor (CNTF)), IL1 subfamily members (IL1R antagonist (A), IL33Rα), and tumor necrosis factor (TNF)α. Patient subsets identified from this 10-mediator profile did not differ with regard to disease stage, human papilloma virus (HPV) status, CRP levels, or death cause. Increased CRP, IL6, and IL1RA levels were independent markers for HNSCC-related death in the whole patient population. Furthermore, gp130, IL6Rα, and IL31 were suggested to predict prognosis among tumor HPV-negative patients. Only IL6 predicted survival in HPV-positive patients. Finally, we did a clustering analysis of HPV-negative patients based on six acute phase mediators that showed significant or borderline association with prognosis in Kaplan–Meier analyses; three subsets could then be identified, and they differed in survival (p < 0.001). To conclude, (i) HPV-negative and HPV-positive HNSCC patients show similar variations of their systemic acute phase profiles; (ii) the prognostic impact of single mediators differs between these two patient subsets; and (iii) for HPV-negative patients, acute phase profiling identifies three patient subsets that differ significantly in survival.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe acute phase reaction and its prognostic impact in patients with head and neck squamous cell carcinoma: Single biomarkers including c-reactive protein versus biomarker profilesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.articlenumber418en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/biomedicines8100418
dc.identifier.cristin1845914
dc.source.journalBiomedicinesen_US
dc.source.408:418
dc.source.1410
dc.identifier.citationBiomedicines. 2020, 8(10), 418en_US
dc.source.volume8en_US
dc.source.issue10en_US


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