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dc.contributor.authorRafati, Nima
dc.contributor.authorChen, Junfeng
dc.contributor.authorHerpin, Amaury
dc.contributor.authorPettersson, Mats
dc.contributor.authorHan, Fan
dc.contributor.authorFeng, Chungang
dc.contributor.authorWallerman, Ola
dc.contributor.authorRubin, Carl-Johan
dc.contributor.authorPéron, Sandrine
dc.contributor.authorCocco, Arianna
dc.contributor.authorLarsson, Mårten
dc.contributor.authorTrötschel, Christian
dc.contributor.authorPoetsch, Ansgar
dc.contributor.authorKorsching, Kai
dc.contributor.authorBönigk, Wolfgang
dc.contributor.authorKörschen, Heinz G.
dc.contributor.authorBerg, Florian
dc.contributor.authorFolkvord, Arild
dc.contributor.authorBenjamin Kaupp, Kaupp
dc.contributor.authorSchartl, Manfred
dc.contributor.authorAndersson, Leif
dc.PublishedProceedings of the National Academy of Sciences of the United States of America. 2020, 117 (39), 24359-24368.
dc.description.abstractThe mechanisms underlying sex determination are astonishingly plastic. Particularly the triggers for the molecular machinery, which recalls either the male or female developmental program, are highly variable and have evolved independently and repeatedly. Fish show a huge variety of sex determination systems, including both genetic and environmental triggers. The advent of sex chromosomes is assumed to stabilize genetic sex determination. However, because sex chromosomes are notoriously cluttered with repetitive DNA and pseudogenes, the study of their evolution is hampered. Here we reconstruct the birth of a Y chromosome present in the Atlantic herring. The region is tiny (230 kb) and contains only three intact genes. The candidate male-determining gene BMPR1BBY encodes a truncated form of a BMP1B receptor, which originated by gene duplication and translocation and underwent rapid protein evolution. BMPR1BBY phosphorylates SMADs in the absence of ligand and thus has the potential to induce testis formation. The Y region also contains two genes encoding subunits of the sperm-specific Ca2+ channel CatSper required for male fertility. The herring Y chromosome conforms with a characteristic feature of many sex chromosomes, namely, suppressed recombination between a sex-determining factor and genes that are beneficial for the given sex. However, the herring Y differs from other sex chromosomes in that suppression of recombination is restricted to an ∼500-kb region harboring the male-specific and sex-associated regions. As a consequence, any degeneration on the herring Y chromosome is restricted to those genes located in the small region affected by suppressed recombination.en_US
dc.publisherNational Academy of Sciencesen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleReconstruction of the birth of a male sex chromosome present in Atlantic herringen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.relation.projectNorges forskningsråd: 254774en_US
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. 2020, 117 (39), 24359-24368en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal