dc.contributor.author | Luongo, Timothy S. | |
dc.contributor.author | Eller, Jared M. | |
dc.contributor.author | Lu, Mu-Jie | |
dc.contributor.author | Niere, Marc | |
dc.contributor.author | Raith, Fabio | |
dc.contributor.author | Perry, Caroline | |
dc.contributor.author | Bornstein, Marc R. | |
dc.contributor.author | Oliphint, Paul | |
dc.contributor.author | Wang, Lin | |
dc.contributor.author | McReynolds, Melanie R. | |
dc.contributor.author | Migaud, Marie E. | |
dc.contributor.author | Rabinowitz, Joshua D. | |
dc.contributor.author | Johnson, F. Brad | |
dc.contributor.author | Johnsson, Kai | |
dc.contributor.author | Ziegler, Mathias | |
dc.contributor.author | Cambronne, Xiaolu A. | |
dc.contributor.author | Baur, Joseph A. | |
dc.date.accessioned | 2021-05-03T13:17:53Z | |
dc.date.available | 2021-05-03T13:17:53Z | |
dc.date.created | 2020-09-23T12:16:53Z | |
dc.date.issued | 2020 | |
dc.Published | Nature. 2020, 1-25. | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.uri | https://hdl.handle.net/11250/2753314 | |
dc.description.abstract | Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in yeast and plants1,2, but their existence in mammals remains controversial3,4,5. Here we demonstrate that mammalian mitochondria can take up intact NAD+, and identify SLC25A51 (also known as MCART1)—an essential6,7 mitochondrial protein of previously unknown function—as a mammalian mitochondrial NAD+ transporter. Loss of SLC25A51 decreases mitochondrial—but not whole-cell—NAD+ content, impairs mitochondrial respiration, and blocks the uptake of NAD+ into isolated mitochondria. Conversely, overexpression of SLC25A51 or SLC25A52 (a nearly identical paralogue of SLC25A51) increases mitochondrial NAD+ levels and restores NAD+ uptake into yeast mitochondria lacking endogenous NAD+ transporters. Together, these findings identify SLC25A51 as a mammalian transporter capable of importing NAD+ into mitochondria. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.title | SLC25A51 is a mammalian mitochondrial NAD+ transporter | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | Copyright © 2020, The Author(s), under exclusive licence to Springer Nature Limited. | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1038/s41586-020-2741-7 | |
dc.identifier.cristin | 1832480 | |
dc.source.journal | Nature | en_US |
dc.source.pagenumber | 174–179 | en_US |
dc.identifier.citation | Nature. 2020, 588, 174–179. | en_US |
dc.source.volume | 588 | en_US |