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dc.contributor.authorLuongo, Timothy S.
dc.contributor.authorEller, Jared M.
dc.contributor.authorLu, Mu-Jie
dc.contributor.authorNiere, Marc
dc.contributor.authorRaith, Fabio
dc.contributor.authorPerry, Caroline
dc.contributor.authorBornstein, Marc R.
dc.contributor.authorOliphint, Paul
dc.contributor.authorWang, Lin
dc.contributor.authorMcReynolds, Melanie R.
dc.contributor.authorMigaud, Marie E.
dc.contributor.authorRabinowitz, Joshua D.
dc.contributor.authorJohnson, F. Brad
dc.contributor.authorJohnsson, Kai
dc.contributor.authorZiegler, Mathias
dc.contributor.authorCambronne, Xiaolu A.
dc.contributor.authorBaur, Joseph A.
dc.date.accessioned2021-05-03T13:17:53Z
dc.date.available2021-05-03T13:17:53Z
dc.date.created2020-09-23T12:16:53Z
dc.date.issued2020
dc.PublishedNature. 2020, 1-25.
dc.identifier.issn0028-0836
dc.identifier.urihttps://hdl.handle.net/11250/2753314
dc.description.abstractMitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been identified in yeast and plants1,2, but their existence in mammals remains controversial3,4,5. Here we demonstrate that mammalian mitochondria can take up intact NAD+, and identify SLC25A51 (also known as MCART1)—an essential6,7 mitochondrial protein of previously unknown function—as a mammalian mitochondrial NAD+ transporter. Loss of SLC25A51 decreases mitochondrial—but not whole-cell—NAD+ content, impairs mitochondrial respiration, and blocks the uptake of NAD+ into isolated mitochondria. Conversely, overexpression of SLC25A51 or SLC25A52 (a nearly identical paralogue of SLC25A51) increases mitochondrial NAD+ levels and restores NAD+ uptake into yeast mitochondria lacking endogenous NAD+ transporters. Together, these findings identify SLC25A51 as a mammalian transporter capable of importing NAD+ into mitochondria.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.titleSLC25A51 is a mammalian mitochondrial NAD+ transporteren_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright © 2020, The Author(s), under exclusive licence to Springer Nature Limited.en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.doi10.1038/s41586-020-2741-7
dc.identifier.cristin1832480
dc.source.journalNatureen_US
dc.source.pagenumber174–179en_US
dc.identifier.citationNature. 2020, 588, 174–179.en_US
dc.source.volume588en_US


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