dc.contributor.author | Kleinmanns, Katrin | |
dc.contributor.author | Fosse, Vibeke Samuelsen | |
dc.contributor.author | Bjørge, Line | |
dc.contributor.author | McCormack, Emmet | |
dc.date.accessioned | 2021-05-18T11:34:14Z | |
dc.date.available | 2021-05-18T11:34:14Z | |
dc.date.created | 2020-11-30T10:26:51Z | |
dc.date.issued | 2020 | |
dc.Published | Journal of Personalized Medicine. 2020, 10:255 (4), 1-18. | |
dc.identifier.uri | https://hdl.handle.net/11250/2755456 | |
dc.description.abstract | Complete cytoreductive surgery is the cornerstone of the treatment of epithelial ovarian cancer (EOC). The application of fluorescence image-guided surgery (FIGS) allows for the increased intraoperative visualization and delineation of malignant lesions by using fluorescently labeled targeting biomarkers, thereby improving intraoperative guidance. CD24, a small glycophosphatidylinositol-anchored cell surface receptor, is overexpressed in approximately 70% of solid cancers, and has been proposed as a prognostic and therapeutic tumor-specific biomarker for EOC. Recently, preclinical studies have demonstrated the benefit of CD24-targeted contrast agents for non-invasive fluorescence imaging, as well as improved tumor resection by employing CD24-targeted FIGS in orthotopic patient-derived xenograft models of EOC. The successful detection of miniscule metastases denotes CD24 as a promising biomarker for the application of fluorescence-guided surgery in EOC patients. The aim of this review is to present the clinical and preclinically evaluated biomarkers for ovarian cancer FIGS, highlight the strengths of CD24, and propose a future bimodal approach combining CD24-targeted fluorescence imaging with radionuclide detection and targeted therapy. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The emerging role of cd24 in cancer theranostics—a novel target for fluorescence image-guided surgery in ovarian cancer and beyond | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2020 by the Authors. | en_US |
dc.source.articlenumber | 255 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3390/jpm10040255 | |
dc.identifier.cristin | 1853979 | |
dc.source.journal | Journal of Personalized Medicine | en_US |
dc.source.40 | 10:255 | |
dc.source.14 | 4 | |
dc.identifier.citation | Journal of Personalized Medicine. 2020, 10 (4), 255 | en_US |
dc.source.volume | 10 | en_US |
dc.source.issue | 4 | en_US |