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dc.contributor.authorKuiper, Ingrid Nordeide
dc.contributor.authorMarkevych, Iana
dc.contributor.authorAccordini, Simone
dc.contributor.authorBertelsen, Randi Jacobsen
dc.contributor.authorBråbäck, Lennart
dc.contributor.authorChristensen, Jesper Heile
dc.contributor.authorForsberg, Bertil
dc.contributor.authorHalvorsen, Thomas
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorHertel, Ole
dc.contributor.authorHoek, Gerard
dc.contributor.authorHolm, Mathias
dc.contributor.authorde Hoogh, Kees
dc.contributor.authorJanson, Christer
dc.contributor.authorMalinovschi, Anderi
dc.contributor.authorMarcon, Alessandro
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorJohannessen, Ane
dc.date.accessioned2021-05-21T09:06:53Z
dc.date.available2021-05-21T09:06:53Z
dc.date.created2020-10-20T16:14:40Z
dc.date.issued2020
dc.PublishedInternational Journal of Environmental Research and Public Health (IJERPH). 2020, :5828 (16), 1-14.
dc.identifier.issn1661-7827
dc.identifier.urihttps://hdl.handle.net/11250/2755990
dc.description.abstractWe investigated if greenness and air pollution exposure in parents’ childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O3) (µg/m3) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0–18 years old and offspring 0–10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM2.5 and PM10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32–3.78, OR 2.27, 95%CI 1.36–3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11–0.87). Hay fever risk increased for offspring of fathers with medium O3 exposure (OR 4.15, 95%CI 1.28–13.50) and mothers with high PM10 exposure (OR 2.66, 95%CI 1.19–5.91). The effect of maternal PM10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring’s own exposures. Paternal O3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAssociations of preconception exposure to air pollution and greenness with offspring asthma and hay feveren_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 by the Authors.en_US
dc.source.articlenumber5828en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/ijerph17165828
dc.identifier.cristin1840975
dc.source.journalInternational Journal of Environmental Research and Public Health (IJERPH)en_US
dc.source.40:5828
dc.source.1416
dc.identifier.citationInternational Journal of Environmental Research and Public Health (IJERPH). 2020, 17 (16), 5828en_US
dc.source.volume17en_US
dc.source.issue16en_US


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