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dc.contributor.authorFrank, Anna-Simone
dc.contributor.authorLarripa, Kamila
dc.contributor.authorRyu, Hwayeon
dc.contributor.authorSnodgrass, Ryan
dc.contributor.authorRöblitz, Susanna
dc.date.accessioned2021-05-26T11:08:42Z
dc.date.available2021-05-26T11:08:42Z
dc.date.created2020-10-22T16:18:11Z
dc.date.issued2020
dc.identifier.issn0022-5193
dc.identifier.urihttps://hdl.handle.net/11250/2756433
dc.description.abstractIn this paper, we present and analyze a mathematical model for polarization of a single macrophage which, despite its simplicity, exhibits complex dynamics in terms of multistability. In particular, we demonstrate that an asymmetry in the regulatory mechanisms and parameter values is important for observing multiple phenotypes. Bifurcation and sensitivity analyses show that external signaling cues are necessary for macrophage commitment and emergence to a phenotype, but that the intrinsic macrophage pathways are equally important. Based on our numerical results, we formulate hypotheses that could be further investigated by laboratory experiments to deepen our understanding of macrophage polarization.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleBifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarizationen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.articlenumber110511en_US
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1
dc.identifier.doi10.1016/j.jtbi.2020.110511
dc.identifier.cristin1841610
dc.source.journalJournal of Theoretical Biologyen_US
dc.identifier.citationJournal of Theoretical Biology. 2020, 509, 110511en_US
dc.source.volume509en_US


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