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dc.contributor.authorTourniere, Oceane Barbara
dc.contributor.authorDolan, David William Peter
dc.contributor.authorRichards, Gemma Sian
dc.contributor.authorSunagar, Kartik
dc.contributor.authorColumbus-Shenkar, Yaara Y
dc.contributor.authorMoran, Yehu
dc.contributor.authorRentzsch, Fabian
dc.date.accessioned2021-06-15T12:39:07Z
dc.date.available2021-06-15T12:39:07Z
dc.date.created2021-01-27T12:26:55Z
dc.date.issued2020-03
dc.PublishedCell reports. 2020, 30 (13), 4473-4489.
dc.identifier.issn2211-1247
dc.identifier.urihttps://hdl.handle.net/11250/2759576
dc.description.abstractTerminal selectors are transcription factors that control the morphological, physiological, and molecular features that characterize distinct cell types. Here, we show that, in the sea anemone Nematostella vectensis, NvPOU4 is expressed in post-mitotic cells that give rise to a diverse set of neural cell types, including cnidocytes and NvElav1-expressing neurons. Morphological analyses of NvPOU4 mutants crossed to transgenic reporter lines show that the loss of NvPOU4 does not affect the initial specification of neural cells. Transcriptomes derived from the mutants and from different neural cell populations reveal that NvPOU4 is required for the execution of the terminal differentiation program of these neural cells. These findings suggest that POU4 genes have ancient functions as terminal selectors for morphologically and functionally disparate types of neurons and they provide experimental support for the relevance of terminal selectors for understanding the evolution of cell types.en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleNvPOU4/Brain3 Functions as a Terminal Selector Gene in the Nervous System of the Cnidarian Nematostella vectensisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 The Authorsen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1016/j.celrep.2020.03.031
dc.identifier.cristin1880264
dc.source.journalCell reportsen_US
dc.source.4030
dc.source.1413
dc.source.pagenumber4473-4489en_US
dc.identifier.citationCell reports. 2020, 30 (13), 4473-4489en_US
dc.source.volume30en_US
dc.source.issue13en_US


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