Show simple item record

dc.contributor.authorTjensvoll, Anne Bolette
dc.contributor.authorLauvsnes, Maria Boge
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorKvaløy, Jan Terje
dc.contributor.authorKvivik, Ingeborg
dc.contributor.authorMaroni, Stian
dc.contributor.authorGreve, Ole Jacob
dc.contributor.authorBeyer, Mona K.
dc.contributor.authorHirohata, Shunsei
dc.contributor.authorPutterman, Chaim
dc.contributor.authorAlves, Guido Werner
dc.contributor.authorHarboe, Erna
dc.contributor.authorBlennow, Kaj
dc.contributor.authorGøransson, Lasse
dc.contributor.authorOmdal, Roald
dc.PublishedJournal of Neurology. 2020, .
dc.description.abstractBackground To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL in CSF from 52 patients with lupus and 54 with pSS and explored associations with clinical, structural, immunological and biochemical abnormalities. Methods In CSF, we measured NfL, anti-P antibodies, protein S100B and TWEAK by ELISA and anti-NR2 antibodies by electrochemiluminescence. Anti-phospholipid antibodies and routine immunological tests were performed in blood. IgG and albumin were measured in CSF and serum for assessment of the blood–brain barrier function (Q-albumin) and intrathecal IgG production (IgG index). Cerebral MRI and neuropsychological testing were performed. Results A multivariable regression model showed that increasing CSF anti-NR2 antibody levels were associated with increasing NfL levels in patients with SLE (B 1.27, 95% CI 0.88–1.65, p < 0.001). Age contributed significantly in the model (B 0.04, 95% CI 0.03–0.05, p < 0.001). Similar findings were observed in the pSS group. Adjusted for age and sex, no associations were found between NfL levels and any MRI data. In SLE patients, higher NfL concentrations were associated with impairments in psychomotor speed and motor function, and in pSS with motor dysfunction. These associations remained in multivariable regression models. Conclusions Increased concentration of NfL in CSF is a marker of cerebral involvement in patients with SLE and pSS, is strongly associated with the presence of anti-NR2 antibodies, and correlates with cognitive impairment in several domains.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleNeurofilament light is a biomarker of brain involvement in lupus and primary Sjögren’s syndromeen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.journalJournal of Neurologyen_US
dc.identifier.citationJournal of Neurology. 2020, 268, 1385–1394en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal