Show simple item record

dc.contributor.authorTotland, Christian
dc.contributor.authorThomas, Peter
dc.contributor.authorHolst, Bodil
dc.contributor.authorAkhtar, Naureen
dc.contributor.authorHovdenes, Jostein
dc.contributor.authorSkodvin, Tore
dc.date.accessioned2021-07-02T11:12:27Z
dc.date.available2021-07-02T11:12:27Z
dc.date.created2020-06-26T11:28:44Z
dc.date.issued2020
dc.identifier.issn1053-0509
dc.identifier.urihttps://hdl.handle.net/11250/2763102
dc.description.abstractA significant challenge concerning the development of fluorescence lifetime (FL) based pH sensors is the paucity of fluorophores with sufficiently large FL variation with pH. Acridine is amongst the indicators with highest fluoresce lifetime responses to pH, with a change in lifetime of about 13 ns within a pH range of 5–8. Here we examine the two acridine derivatives, 9-acridinemethanamine (9-AMA) and acridine-9-carbaldehyde (9-ACA) in terms of their FL pH sensitivity and pH sensing range. Both indicators are characterized when dissolved in buffer solutions, as well as when immobilized in support materials. 9-AMA has a change in FL of 11 ns between pH 2–5, both when dissolved in solution and when immobilized in surfactant-filled mesoporous silica. The FL of 9-ACA is not sensitive to pH when dissolved in buffer solutions; however, when covalently bound to amine-modified silica, its FL changes 15 ns between pH 3–6. 9-AMA and 9-ACA represent promising FL in the pH range of pH 2–6, and could potentially form the basis of new FL pH sensors.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.title9-Acridinemethanamine and Acridine-9-Carboxaldehyde as Potential Fluorescence Lifetime pH Indicatorsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2020 The Authorsen_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.doi10.1007/s10895-020-02564-5
dc.identifier.cristin1817261
dc.source.journalJournal of Fluorescenceen_US
dc.source.pagenumber901-906en_US
dc.relation.projectNorges forskningsråd: 269090en_US
dc.identifier.citationJournal of Fluorescence. 2020, 30, 901-906en_US
dc.source.volume30en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal