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dc.contributor.authorvan Dellen, Edwin
dc.contributor.authorBörner, Corinna
dc.contributor.authorSchutte, Maya
dc.contributor.authorvan Montfort, Simone
dc.contributor.authorAbramovic, Lucija
dc.contributor.authorBoks, Marco P.
dc.contributor.authorCahn, Wiepke
dc.contributor.authorvan Haren, Neeltje E.M.
dc.contributor.authorMandl, René
dc.contributor.authorStam, Cornelis J.
dc.contributor.authorSommer, Iris Else Clara
dc.description.abstractPsychotic experiences have been proposed to lie on a spectrum, ranging from subclinical experiences to treatment-resistant schizophrenia. We aimed to characterize functional connectivity and brain network characteristics in relation to the schizophrenia spectrum and bipolar disorder with psychosis to disentangle neural correlates to psychosis. Additionally, we studied antipsychotic medication and lithium effects on network characteristics. We analyzed functional connectivity strength and network topology in 487 resting-state functional MRI scans of individuals with schizophrenia spectrum disorder (SCZ), bipolar disorder with a history of psychotic experiences (BD), treatment-naïve subclinical psychosis (SCP), and healthy controls (HC). Since differences in connectivity strength may confound group comparisons of brain network topology, we analyzed characteristics of the minimum spanning tree (MST), a relatively unbiased backbone of the network. SCZ and SCP subjects had a lower connectivity strength than BD and HC individuals but showed no differences in network topology. In contrast, BD patients showed a less integrated network topology but no disturbances in connectivity strength. No differences in outcome measures were found between SCP and SCZ, or between BD patients that used antipsychotic medication or lithium and those that did not. We conclude that functional networks in patients prone to psychosis have different signatures for chronic SCZ patients and SCP compared to euthymic BD patients, with a limited role for medication. Connectivity strength effects may have confounded previous studies, as no functional network alterations were found in SCZ after strict correction for connectivity strength.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleFunctional brain networks in the schizophrenia spectrum and bipolar disorder with psychosisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright the authorsen_US
dc.source.journalNPJ Schizophreniaen_US
dc.identifier.citationNPJ Schizophrenia. 2020, 6, 22.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal