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dc.contributor.authorFaay, Margo D.M.
dc.contributor.authorvan Baal, G. Caroline M.
dc.contributor.authorArango, Celso
dc.contributor.authorDiaz-Caneja, Covadonga M.
dc.contributor.authorBerger, Gregor
dc.contributor.authorLeucht, Stefan
dc.contributor.authorBobes, Julio
dc.contributor.authorSaiz, Pilar A.
dc.contributor.authorGarcía-Portilla, María Paz
dc.contributor.authorvan de Brug, Resy
dc.contributor.authorPetter, Jocelyn
dc.contributor.authorWinter-van Rossum, Inge
dc.contributor.authorSommer, Iris Else Clara
dc.description.abstractAim: The aim of this paper is to determine clinical factors related to hostility and disturbing and aggressive behaviour and to examine the effect of medication on these behaviours in FEP. Methods: Data from phase I and II of the OPTiMiSE trial are used. Outcome measures are the hostility item of the Positive and Negative Syndrome Scale (PANSS P7) and the disturbing and aggressive behaviour domain of the Personal and Social Performance scale (PSP-D). Results: Moderate, severe or extreme hostility (PANSS P7 > 3) was present in 42 patients (9.4%). The PANSS P7 and PSP-D were low to moderate but significantly associated with the selected PANSS items: delusions, hallucinatory behaviour, excitement, tension, uncooperativeness, unusual thought content, impulsivity, and lack of judgement and insight. In a subsample of 185 patients (41.5%) with baseline PANSS P7 > 1, the PANSS P7 and PSP-D scores improved in the first 4 weeks of amisulpride treatment. This effect remained significant after controlling for baseline positive symptoms (PANSS P1-P6). No significant differences were found between olanzapine and amisulpride in the second phase of the trial. Conclusion: Clinical risk factors such as poor impulse control, uncooperativeness and excitement could help clinicians in detecting and treating hostile and aggressive behaviour in FEP. Amisulpride could be an effective antipsychotic choice in the treatment of FEP patients who express hostile or aggressive behaviour. Future research is needed to compare the effects of amisulpride and olanzapine on hostility in FEP during the first weeks of treatment.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleHostility and aggressive behaviour in first episode psychosis: Results from the OPTiMiSE trialen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 the authorsen_US
dc.source.journalSchizophrenia Researchen_US
dc.identifier.citationSchizophrenia Research. 2020, 223, 271-278.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal