Vis enkel innførsel

dc.contributor.authorMosleth, Ellen Færgestad
dc.contributor.authorVedeler, Christian Alexander
dc.contributor.authorLiland, Kristian Hovde
dc.contributor.authorMcLeod, Anette
dc.contributor.authorBringeland, Gerd Haga
dc.contributor.authorKroondijk, Liesbeth
dc.contributor.authorBerven, Frode Steingrimsen
dc.contributor.authorLysenko, Artem
dc.contributor.authorRawlings, Christopher J.
dc.contributor.authorEl-Hajj Eid, Karim
dc.contributor.authorOpsahl, Jill Anette
dc.contributor.authorGjertsen, Bjørn Tore
dc.contributor.authorMyhr, Kjell-Morten
dc.contributor.authorGavasso, Sonia
dc.date.accessioned2021-07-29T12:02:41Z
dc.date.available2021-07-29T12:02:41Z
dc.date.created2021-03-29T12:35:32Z
dc.date.issued2021-02-18
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2765626
dc.description.abstractDespite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease heterogeneity. We previously reported explorative multivariate analysis by hierarchical clustering of proteomics data of MS patients and controls, which resulted in two groups of individuals. Grouping reflected increased levels of intrathecal inflammatory response proteins and decreased levels of proteins involved in neural development in one group relative to the other group. MS patients and controls were present in both groups. Here we reanalysed these data and we also reanalysed data from an independent cohort of patients diagnosed with clinically isolated syndrome (CIS), who have symptoms of MS without evidence of dissemination in space and/or time. Some, but not all, CIS patients had intrathecal inflammation. The analyses reported here identified a common protein signature of MS/CIS that was not linked to elevated intrathecal inflammation. The signature included low levels of complement proteins, semaphorin-7A, reelin, neural cell adhesion molecules, inter-alpha-trypsin inhibitor heavy chain H2, transforming growth factor beta 1, follistatin-related protein 1, malate dehydrogenase 1 cytoplasmic, plasma retinol-binding protein, biotinidase, and transferrin, all known to play roles in neural development. Low levels of these proteins suggest that MS/CIS patients suffer from abnormally low oxidative capacity that results in disrupted neural development from an early stage of the disease.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Author(s) 2021en_US
dc.source.articlenumber4087en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1038/s41598-021-82388-w
dc.identifier.cristin1901610
dc.source.journalScientific Reportsen_US
dc.relation.projectNorges forskningsråd: 224921en_US
dc.relation.projectNorges forskningsråd: 262300en_US
dc.relation.projectNorges forskningsråd: 262308en_US
dc.relation.projectNorges forskningsråd: 224820en_US
dc.relation.projectNofima AS: 201702en_US
dc.relation.projectNorges forskningsråd: 225096en_US
dc.relation.projectNofima AS: 201701en_US
dc.identifier.citationScientific Reports. 2021, 11, 4087.en_US
dc.source.volume11en_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal