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dc.contributor.authorAbolpour Mofrad, Samaneh
dc.contributor.authorLundervold, Astri Johansen
dc.contributor.authorVik, Alexandra
dc.contributor.authorLundervold, Alexander Selvikvåg
dc.description.abstractThe concept of Mild Cognitive Impairment (MCI) is used to describe the early stages of Alzheimer’s disease (AD), and identification and treatment before further decline is an important clinical task. We selected longitudinal data from the ADNI database to investigate how well normal function (HC, n= 134) vs. conversion to MCI (cMCI, n= 134) and stable MCI (sMCI, n=333) vs. conversion to AD (cAD, n= 333) could be predicted from cognitive tests, and whether the predictions improve by adding information from magnetic resonance imaging (MRI) examinations. Features representing trajectories of change in the selected cognitive and MRI measures were derived from mixed effects models and used to train ensemble machine learning models to classify the pairs of subgroups based on a subset of the data set. Evaluation in an independent test set showed that the predictions for HC vs. cMCI improved substantially when MRI features were added, with an increase in F1-score from 60 to 77%. The F1-scores for sMCI vs. cAD were 77% without and 78% with inclusion of MRI features. The results are in-line with findings showing that cognitive changes tend to manifest themselves several years after the Alzheimer’s disease is well-established in the brain.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCognitive and MRI trajectories for prediction of Alzheimer’s diseaseen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2021 The Authorsen_US
dc.source.journalScientific Reportsen_US
dc.relation.projectBergens forskningsstiftelse: BFS2018TMT07en_US
dc.subject.nsiVDP::Datateknologi: 551en_US
dc.subject.nsiVDP::Computer technology: 551en_US
dc.subject.nsiVDP::Datateknologi: 551en_US
dc.subject.nsiVDP::Computer technology: 551en_US
dc.identifier.citationScientific Reports. 2021, 11, 2122en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal