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dc.contributor.authorVogelezang, Suzanne
dc.contributor.authorBradfield, Jonathan P.
dc.contributor.authorAhluwalia, Tarunveer S.
dc.contributor.authorCurtin, John A.
dc.contributor.authorLakka, Timo A.
dc.contributor.authorGrarup, Niels
dc.contributor.authorScholz, Markus
dc.contributor.authorvan der Most, Peter J.
dc.contributor.authorMonnereau, Claire
dc.contributor.authorStergiakouli, Evie
dc.contributor.authorHeiskala, Anni
dc.contributor.authorHorikoshi, Momoko
dc.contributor.authorFedko, Iryna O.
dc.contributor.authorVilor-Tejedor, Natalia
dc.contributor.authorCousminer, Diana L.
dc.contributor.authorStandl, Marie
dc.contributor.authorWang, Carol A.
dc.contributor.authorViikari, Jorma
dc.contributor.authorGeller, Frank
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorPitkänen, Niina
dc.contributor.authorChesi, Alessandra
dc.contributor.authorBacelis, Jonas
dc.contributor.authorYengo, Loic
dc.contributor.authorTorrent, Maties
dc.contributor.authorNtalla, Ioanna
dc.contributor.authorHelgeland, Øyvind
dc.contributor.authorSelzam, Saskia
dc.contributor.authorVonk, Judith M.
dc.contributor.authorZafarmand, Mohammed H.
dc.contributor.authorHeude, Barbara
dc.contributor.authorFarooqi, Ismaa Sadaf
dc.contributor.authorAlyass, Akram
dc.contributor.authorBeaumont, Robin N.
dc.contributor.authorHave, Christian T.
dc.contributor.authorRzehak, Peter
dc.contributor.authorBilbao, Jose Ramon
dc.contributor.authorSchnurr, Theresia M.
dc.contributor.authorBarroso, Inês
dc.contributor.authorBønnelykke, Klaus
dc.contributor.authorBeilin, Lawrence J.
dc.contributor.authorCarstensen, Lisbeth
dc.contributor.authorCharles, Marie-Aline
dc.contributor.authorChawes, Bo
dc.contributor.authorClément, Karine
dc.contributor.authorClosa-Monasterolo, Ricardo
dc.contributor.authorCustovic, Adnan
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorVaudel, Marc
dc.contributor.authorNjølstad, Pål Rasmus
dc.description.abstractThe genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleNovel loci for childhood body mass index and shared heritability with adult cardiometabolic traitsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2020 The Authorsen_US
dc.source.journalPLoS Geneticsen_US
dc.identifier.citationPLoS Genetics. 2020, 16 (10), e1008718.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal