dc.contributor.author | Dhillon, Amandeep Kaur | |
dc.contributor.author | Rupp, Christian | |
dc.contributor.author | Bergquist, Annika | |
dc.contributor.author | Voitl, Robert | |
dc.contributor.author | Folseraas, Trine | |
dc.contributor.author | Trøseid, Marius | |
dc.contributor.author | Midttun, Øivind | |
dc.contributor.author | Ueland, Per Magne | |
dc.contributor.author | Karlsen, Tom Hemming | |
dc.contributor.author | Vesterhus, Mette Nåmdal | |
dc.contributor.author | Kummen, Martin | |
dc.contributor.author | Hov, Johannes Espolin Roksund | |
dc.date.accessioned | 2021-08-18T08:20:44Z | |
dc.date.available | 2021-08-18T08:20:44Z | |
dc.date.created | 2021-06-01T13:45:26Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0036-5521 | |
dc.identifier.uri | https://hdl.handle.net/11250/2770006 | |
dc.description.abstract | Background and aims
Biomarkers of inflammation may be of clinical utility in primary sclerosing cholangitis (PSC). We aimed to investigate the interferon gamma-related biomarkers neopterin and kynurenine–tryptophanratio (KT-ratio) in PSC.
Methods
Circulating neopterin, tryptophan and kynurenine were measured with LC-MS/MS in multiple cross-sectional cohorts comprising in total of 524 PSC patients and 100 healthy controls from Norway, Germany and Sweden.
Results
Neopterin and KT-ratio were significantly increased in PSC patients compared with controls in both a discovery and a validation cohort from Norway. Furthermore, high neopterin and KT-ratio levels were associated with a shorter transplantation-free survival in the PSC patients in the Norwegian discovery cohort and the German validation cohort. However, in the validation PSC cohort from Sweden, no relationship between neopterin and KT-ratio and liver transplantation-free survival was observed. The correlations between neopterin and KT-ratio were moderate to strong and similar in all cohorts (rho 0.50–0.67). Neopterin and KT-ratio also correlated with C-reactive protein (rho 0.17-0.63) and revised Mayo risk score (rho 0.23–0.42) in all cohorts.
Conclusions
Neopterin and KT-ratio were elevated in PSC and associated with liver transplantation-free survival in two independent PSC cohorts, highlighting a possible role of interferon gamma-driven inflammation in the pathogenesis. However, the lack of association with survival in one of the cohorts reduces the potential clinical value of neopterin and KT-ratioas biomarkers and highlights the need to validate new biomarkers in PSC in multiple cohorts. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2021 The Author(s). | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1080/00365521.2021.1880627 | |
dc.identifier.cristin | 1913059 | |
dc.source.journal | Scandinavian Journal of Gastroenterology | en_US |
dc.source.pagenumber | 443-452 | en_US |
dc.identifier.citation | Scandinavian Journal of Gastroenterology. 2021, 56 (4), 443-452. | en_US |
dc.source.volume | 56 | en_US |
dc.source.issue | 4 | en_US |