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dc.contributor.authorCamacho, Marta
dc.contributor.authorMacleod, Angus D.
dc.contributor.authorGrødem, Jodi Maple
dc.contributor.authorEvans, Jonathan R.
dc.contributor.authorBreen, David P.
dc.contributor.authorCummins, G
dc.contributor.authorWijeyekoon, Ruwani
dc.contributor.authorGreenland, Julia
dc.contributor.authorAlves, Guido Werner
dc.contributor.authorTysnes, Ole-Bjørn
dc.contributor.authorLawson, Rachel A.
dc.contributor.authorBarker, Roger A.
dc.contributor.authorWilliams-Gray, Caroline H.
dc.description.abstractConstipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration, composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessed with the MDS-UPDRS constipation item or a comparable categorical scale. Primary PD outcomes of interest were dementia, postural instability and death. PD patients were stratified according to constipation severity at diagnosis: none (n = 313, 67.3%), minor (n = 97, 20.9%) and major (n = 55, 11.8%). Clinical progression to all three outcomes was more rapid in those with more severe constipation at baseline (Kaplan–Meier survival analysis). Cox regression analysis, adjusting for relevant confounders, confirmed a significant relationship between constipation severity and progression to dementia, but not postural instability or death. Early constipation may predict an accelerated progression of neurodegenerative pathology.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleEarly constipation predicts faster dementia onset in Parkinson's diseaseen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright the authors 2021en_US
dc.source.journalNPJ Parkinson's Diseaseen_US
dc.relation.projectNorges forskningsråd: 287842en_US
dc.identifier.citationNPJ Parkinson's Disease. 2021.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal