Show simple item record

dc.contributor.authorSchwinger, Catherine
dc.contributor.authorSharma, Shakun
dc.contributor.authorChandyo, Ram K
dc.contributor.authorHysing, Mari
dc.contributor.authorKvestad, Ingrid
dc.contributor.authorUlak, Manjeswori
dc.contributor.authorRanjitkar, Suman
dc.contributor.authorShrestha, Merina
dc.contributor.authorShrestha, Laxman
dc.contributor.authorMcCann, Adrian
dc.contributor.authorUeland, Per Magne
dc.contributor.authorStrand, Tor Arne
dc.description.abstractThe demand for cobalamin (vitamin B12) and folate is increased during pregnancy, and deficiency during pregnancy may lead to complications and adverse outcomes. Yet, the status of these micronutrients is unknown in many populations. We assessed the concentration of cobalamin, folate and their functional biomarkers, total homocysteine (tHcy) and methylmalonic acid (MMA), in 561 pregnant women enrolled in a community-based randomised controlled trial in Bhaktapur, Nepal. Plasma concentrations of cobalamin, folate, tHcy and MMA were measured and a combined indicator of vitamin B12 status (3cB12) was calculated. We report mean or median concentrations and the prevalence of deficiency according to commonly used cut-offs, and assessed their association with indicators of socio-economic status, and maternal and dietary characteristics by linear regression. Among the women at gestational week less than 15, deficiencies of cobalamin and folate were seen in 24 and 1 %, respectively. Being a vegetarian was associated with lower plasma cobalamin, and a higher socio-economic status was associated with a better micronutrient status. We conclude that cobalamin deficiency defined by commonly used cut-offs was common in Nepalese women in early pregnancy. In contrast, folate deficiency was rare. As there is no consensus on cut-off points for vitamin B12 deficiency during pregnancy, future studies are needed to assess the potential functional consequences of these low values.en_US
dc.publisherCambridge University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCobalamin and folate status in women during early pregnancy in Bhaktapur, Nepalen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright The Author(s), 2021en_US
dc.source.journalJournal of Nutritional Science (JNS)en_US
dc.identifier.citationJournal of Nutritional Science. 2021, 10, e57.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal